Single Source: Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium- Renal and Environmental Science Core (U01-Clinical Trial Not Allowed)
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This funding opportunity aims to support the ongoing research of the Consortium to Study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE), which addresses a significant public health issue affecting rural populations in Low and Middle Income Countries. CKDu leads to kidney failure primarily among young working-age individuals, and while environmental factors are a suspected cause, genetic susceptibility due to family and geographic clustering is also under investigation. Findings from this research are expected to provide critical insights into the development and progression of tubulointerstitial kidney diseases, with relevance to kidney health both internationally and within the U.S. The NIH components NIDDK, NIEHS, and FIC have jointly funded the CURE consortium since 2021, which includes Field Epidemiology Sites, a Renal and Environmental Science Core, and a Data Coordinating Center. This specific funding opportunity requests applications for the Renal and Environmental Science Core, which will provide scientific leadership and support for discovery research into the causes, exposures, and potential treatments for CKDu. The consortium’s collaborative structure is designed to maximize research opportunities and facilitate ancillary studies, advancing understanding of tubulointerstitial kidney disease etiology and informing public health interventions. This is a forecast for a single-source Notice of Funding Opportunity, with applications to be peer-reviewed and funded based on merit.
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The purpose of this funding opportunity is to advance the NIH mission by supporting the continuation of the Consortium to Study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE).
Chronic Kidney Disease of Uncertain Etiology (CKDu) causes kidney failure in rural areas of many Low and Middle Income Countries, resulting in a large death toll among the young working age population. Environmental factors are suspected to be causative, but family and geographic clustering add consideration of unrecognized genetic susceptibility. The risk factors identified in other countries are encountered by U.S. patients, so this research will offer valuable insights into the development and progression of tubulointerstitial renal diseases, with broad implications for understanding kidney health and disease in the U.S.
NIDDK, NIEHS, and FIC have jointly funded a consortium that includes Field Epidemiology Sites, a Renal and Environmental Science Core, and a Data Coordinating Center to find causes and potential interventions for CKDu since 2021. This NOFO requests applications for the Renal and Environmental Science Core that will provide support and leadership in discovery science. Consortium members will continue to collaborate to maximize scientific opportunities and enable discovery science to understand the etiologies of CKDu, the exposures that initiate and affect progression of tubulointerstitial kidney disease, potential therapeutic targets, and future opportunities for public health interventions. The CURE Consortium will serve as a resource for ancillary studies.
This is a forecast for a single source Notice of Funding Opportunity (NOFO) that will invite application(s) from eligible organizations to apply. Application(s) will be peer-reviewed and only funded if meritorious.