ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV
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The National Institutes of Health, through the NICHD and the Office of AIDS Research, is utilizing the DP2 mechanism to support early-career investigators in conducting transformative research on HIV-related chronic conditions, coinfections, and comorbidities. The initiative focuses on developing preventive and therapeutic strategies by exploring HIV-specific pathways and mechanisms, with a particular emphasis on pediatric and maternal populations. This forecast seeks to build a pipeline of innovative researchers from diverse fields, including artificial intelligence, computer science, engineering, and mathematics, to introduce new approaches to these public health challenges. The program aims to fund pioneering research that deviates from existing concepts and aligns with the scientific priorities of the OAR to address the distinct pathologies associated with HIV-related comorbidities.
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NICHD will advance its mission by using the DP2 mechanism to support early-career investigators conducting pioneering research on HIV-related chronic conditions, coinfections, and comorbidities (3C). Scientific directions will be distinct from concepts and approaches already pursued and consistent with the scientific priorities of the Office of AIDS Research (OAR). HIV-related 3Cs cause significant and different pathology in people with and without HIV. Development of preventive and therapeutic strategies based on understanding HIV-specific pathways and mechanisms, and implementing those strategies is critical, especially in pediatric and maternal populations. All pediatric and maternal populations will be appropriate for study as the focus is on HIV prevention and/or treatment research. A pipeline of innovative researchers from other fields of research including mathematics, engineering, computer science, and AI will bring new ideas and innovative approaches. This NOFO will advance research on an important public health problem by supporting transformative research on HIV 3Cs by investigators in the early stages of an independent career.
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