ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV
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The National Institute of Child Health and Human Development (NICHD) is supporting early-career investigators through the DP2 mechanism to conduct innovative research on HIV-related chronic conditions, coinfections, and comorbidities (3C). This initiative encourages pioneering studies that explore distinct scientific directions aligned with the priorities of the Office of AIDS Research (OAR). The focus is on understanding HIV-specific pathways and mechanisms to develop preventive and therapeutic strategies, especially for pediatric and maternal populations, which are critical in addressing HIV prevention and treatment. This funding opportunity aims to foster a diverse pipeline of innovative researchers, including those from fields like mathematics, engineering, computer science, and artificial intelligence, to bring fresh perspectives and novel methodologies to the study of HIV 3Cs. By promoting transformative research early in investigators’ independent careers, the program seeks to advance knowledge and interventions for a significant public health challenge. The contract is managed by the NIH under the Department of Health and Human Services and was announced in February 2026.
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NICHD will advance its mission by using the DP2 mechanism to support early-career investigators conducting pioneering research on HIV-related chronic conditions, coinfections, and comorbidities (3C). Scientific directions will be distinct from concepts and approaches already pursued and consistent with the scientific priorities of the Office of AIDS Research (OAR). HIV-related 3Cs cause significant and different pathology in people with and without HIV. Development of preventive and therapeutic strategies based on understanding HIV-specific pathways and mechanisms, and implementing those strategies is critical, especially in pediatric and maternal populations. All pediatric and maternal populations will be appropriate for study as the focus is on HIV prevention and/or treatment research. A pipeline of innovative researchers from other fields of research including mathematics, engineering, computer science, and AI will bring new ideas and innovative approaches. This NOFO will advance research on an important public health problem by supporting transformative research on HIV 3Cs by investigators in the early stages of an independent career.
