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This Government Contract opportunity from Department Of Defense was posted on May 21, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Request for Information: Biomolecule Purification

Closed
DARPA-SN-26-66Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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AI Contract Overview

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The Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office is soliciting information on innovative purification methods for large, complex molecules to develop a universal purification platform. This platform aims to separate and recover various large biomolecules with high specificity, purity, and yield from complex mixtures, potentially simplifying and speeding up purification processes by eliminating the need for traditional multistep chromatography techniques. DARPA is particularly interested in understanding current advancements, challenges, and potential new capabilities in purifying biologically produced proteins and other critical biologically derived molecules that could benefit from novel approaches. This Request for Information (RFI) is intended to gather insights that will guide the creation of a new program focused on advancing purification technologies. The solicitation was posted on May 15, 2026, with responses due by June 8, 2026. The effort falls under NAICS code 541715 and is managed by DARPA's Microsystems Technology Office, located in Arlington, VA. Interested parties can direct inquiries to the designated contact via email. The information gathered through this RFI will help shape future research and development initiatives aimed at transforming biomolecule purification science within the Department of Defense framework.

General Info

DARPA seeks innovative purification methods for large biomolecules to develop a universal platform.

Agency

Department Of Defense → Defense Advanced Research Projects Agcy

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

VA

Set-Aside

NONE

Documents

(2)

DARPA-SN-26-66 Amendment 01 - RFI Biomolecule Purification

PDF•amendment

DARPA-SN-26-66 Biomolecule Purification RFI May 15 2026

PDF•rfi

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Timeline

1 update
PhaseClosed
Posted

special-notice

Amendment 1

Contract was updated

Response Deadline

Deadline has passed

Submission Closed

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Organization & Contact Information

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AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy
Contacts1 person available
OfficeARLINGTON, VA, 222032114, USA
Organization / Agency
Department Of Defense → Defense Advanced Research Projects Agcy
Office AddressARLINGTON, VA, 222032114, USA
Contacts
DARPA-SN-26-66 Coordinator
contact@example.gov

Full Description

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The Defense Advanced Research Projects Agency (DARPA) Multi X Office (MXO) seeks information on novel methods for the purification of large complex molecules that will enable the creation of a universal purification platform capable of separating and recovering multiple large and complex molecules with high specificity, purity, and yield from complex feedstock. It is anticipated that such a platform will decrease the time and complexity of purification and eliminate the need for multistep chromatography processes, which DARPA believes to be the state of the art. In addition, this RFI seeks to understand a) the current advances and challenges in the purification of biologically produced proteins, as well as of other critical biologically produced molecules that could benefit from a novel purification approach, and b) new operational capabilities enabled by novel purification approaches. Responses to this RFI will be used to inform the development of a new program.