Avant Garde/Avenir award for Investigators conducting high risk/high reward research on HIV and Substance Use (or Substance Use Disorders)
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The National Institute on Drug Abuse (NIDA), under the National Institutes of Health and the Department of Health and Human Services, is issuing solicitation PAR-27-026 for the Avant Garde/Avenir Award Program. This initiative is designed to support exceptionally creative scientists, including early stage investigators, who propose high risk, high reward, and potentially transformative approaches to major challenges in biomedical and behavioral research. The program specifically targets innovative basic, clinical, translational, and implementation research at the intersection of HIV and substance use or substance use disorders. Utilizing the DP1 activity code, this funding opportunity was posted on June 9, 2026, with application deadlines beginning September 25, 2026, and an expiration date of September 26, 2028. The solicitation is a reissue of previous notices PAR-23-125 and PAR-25-261. Interested investigators with expertise in HIV and substance use are encouraged to develop collaborations and submit applications through the NIH and Grants.gov systems.
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The National Institue on Drug Abuse (NIDA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on pioneering research in HIV and Substance use/substance use disorder (SUD) research. The Avant-Garde Award Program is designed to support exceptionally creative scientists who propose cutting edge high risk and high reward and possibly transformative approaches to major challenges in biomedical and behavioral research on HIV in the context of substance use and/or SUDs. This Program includes supporting early stage investigators (ESI). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the DP1 activity code. Investigators with expertise and insights into this area of substance use and HIV are encouraged to begin to consider applying for this new NOFO.
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