BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program - iTeamBCP (RM1 Clinical Trial Optional)
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Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.
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The National Institutes of Health, led by the National Institute of Neurological Disorders and Stroke and several other participating institutes, plans to release a funding opportunity seeking collaborative research teams to advance understanding of how the nervous system generates mental experience and behavior. The program emphasizes integrative research that combines expertise across multiple disciplines, requiring teams of three to six principal investigators to develop fundamental principles of central nervous system function. Projects must bridge analyses at three interconnected levels: detailed cellular and circuit data, high-resolution in vivo central nervous system recordings, and behavioral analyses of organisms or defined neural systems. Additionally, the initiative encourages the development of innovative tools to address major scientific challenges, with an emphasis on experimental systems that can support broad, multi-scale insights into CNS computations. This upcoming opportunity, to be announced under the RM1 activity code, invites investigators with backgrounds in molecular, cellular, systems, behavioral, computational, and theoretical neuroscience, as well as supporting fields like engineering, data science, mathematics, and physics, to prepare for submission. While applications are not currently being accepted, this notice serves to enable potential applicants to form meaningful collaborations and design projects aligned with the integrative goals of the program. The initiative is part of the BRAIN Initiative's effort to foster innovative, multidisciplinary research teams capable of uncovering generalizable mechanisms underlying brain function and behavior.
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The National Institute of Neurological Disorders and Stroke (NINDS), with other NIH Institutes and Centers (ICs), the National Eye Institute (NEI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute on Drug Abuse (NIDA) National Institute of Mental Health (NIMH), National Center for Complementary and Integrative Health (NCCIH), and Office of Behavioral and Social Sciences Research (OBSSR), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications from teams to understand how the nervous system, from its individual components to its unified whole, gives rise to mental experience and behavior. Teams must integrate distinct expertise of 3-6 PDs/PIs to deliver fundamental principles about central nervous system (CNS) function through theories, models, and approaches that bridge cells, circuits, behavior. Applications must connect these 3 levels of analysis: (1) rich large-scale information about circuit components (e.g., cell types, connectivity), (2) in vivo CNS recordings at cellular and sub-second and temporal resolution, (3) along with analyses of a tractable behavior of an organism or a well-defined neural system. Projects may also include the development of tools and approaches to surmount key research roadblocks. Experimental systems should be chosen for their potential to optimize integrative approaches and reveal generalizable, multi-scale principles about CNS computations underlying function and behavior. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of integrative systems neuroscience are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations from newly formed or established teams, combining expertise in molecular, cellular, systems, behavioral, computational, and theoretical neuroscience, as well as in engineering, data science, mathematics, physics, and statistics, as appropriate, will be encouraged and these investigators should also begin considering applying for this application.
