BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01 Basic Experimental Studies with Humans Required)
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The National Institute of Neurological Disorders and Stroke (NINDS), in collaboration with several other NIH Institutes and Centers, plans to issue a Notice of Funding Opportunity (NOFO) aimed at supporting research involving invasive neural recording and stimulation technologies directly within the human brain. This initiative focuses on fundamental experimental studies designed to explore key aspects of human neuroscience, such as sensory perception, memory, decision-making, emotion, language, and motor activation, through intracranial access made possible by surgical procedures. The research supported by this funding opportunity will offer unique insights that are otherwise unattainable, emphasizing the importance of studies on human brain function that can advance understanding of nervous system disorders and aid in the development of novel therapeutic approaches. The NOFO will utilize the U01 cooperative agreement mechanism and encourages collaborative applications from multidisciplinary teams that bring together expertise from clinicians, scientists, device engineers, statisticians, data scientists, regulatory experts, and ethics specialists. Although applications are not yet being accepted, this advance notice allows potential applicants to form partnerships and develop innovative proposals aligned with the initiative’s goals. Interested researchers are advised to begin preparations for submission, focusing on fundamental neuroscience questions addressed through invasive methodologies that require human subjects. For further information and future application details, contacts are provided through the NIH office coordinating this effort.
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The National Institute of Neurological Disorders and Stroke (NINDS), with other NIH Institutes and Centers (ICs) the National Eye Institute (NEI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute on Drug Abuse (NIDA) National Institute of Mental Health (NIMH), National Center for Complementary and Integrative Health (NCCIH) and Office of Behavioral and Social Sciences Research (OBSSR), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on investigative neuroscience with intracranial access to recording and manipulating the brain directly. Investigations within the human brain offer revolutionary, but challenging, opportunities for experimental investigation in how the human brain senses, perceives, remembers, plans, makes decisions, registers emotions, engages language, and activates movements. By leveraging surgical procedures with direct access to the brain, there is the opportunity to design experiments specifically about human neuroscience in ways that are both uniquely human and otherwise impossible. Fundamental basic research often provides insights relevant to disorders of the nervous system and enables research targeting disease mechanisms or therapeutics. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Applications to this NOFO must propose to investigate fundamental questions in human neuroscience. In addition, collaborative investigations from newly formed or established teams, combining expertise of clinicians, scientists, device engineers, mathematicians, statisticians, data scientists, regulatory specialists and/or ethics specialists, as appropriate, to propose innovative research plans will be encouraged and these investigators should also begin considering applying for this application.