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Centers without Walls for mechanisms of neurodegeneration in Alzheimer’s disease-related dementias (ADRD)

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Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institute of Neurological Disorders and Stroke is establishing a Centers without Walls consortium to support ambitious, interdisciplinary research focused on the mechanisms of neurodegeneration in Alzheimer’s disease-related dementias. This collaborative network aims to bring together diverse expertise from multiple institutions to address complex co-pathologies and disease heterogeneity that individual projects cannot tackle alone. The program will utilize a coordinating center to manage data harmonization, communication, and reproducibility across the network, integrating advanced technologies, clinical science, and human specimens to identify new therapeutic targets and biomarkers. This initiative is aligned with the priorities of the ADRD Summit 2025, specifically focusing on breaking down research silos to create a mechanistic foundation for future translational research. While this is currently a forecast and applications are not yet being solicited, the agency encourages investigators with complementary expertise in ADRD mechanisms and clinical phenotypes to contact program staff to develop collaborative projects.

General Info

NINDS funds interdisciplinary consortium researching Alzheimer’s neurodegeneration mechanisms and therapeutic targets.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
NINDS ADRD Administration and Program Staff
contact@example.gov

Full Description

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The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting ambitious research projects to elucidate mechanisms of neurodegeneration in Alzheimer’s disease-related dementias (ADRD) organized as a “Center without Walls” consortium. NINDS Centers without Walls are collaborative research networks that bring together diverse expertise from different institutions to tackle complex neurological problems that are not tractable by individual research projects.

This program is considering using an activity code, such as the RM1, that enables interdisciplinary research consortia capable of identifying and characterizing novel ADRD mechanisms. Teams may include cross-disciplinary and cross-specialty expertise to address the complex co-pathologies, mixed etiologies, and disease heterogeneity in ADRD.

This program is anticipated to support teams that can combine multiple approaches, such as state-of-the-art technologies, disease-relevant models, clinical science, and human specimens, to investigate unique disease mechanisms and identify new therapeutic targets, biomarkers, and other factors influencing ADRD susceptibility, resilience, and pathology. One awardee team would serve as a coordinating center for all awardees to facilitate recurring meetings, data harmonization and sharing, cross-site communication, and support the implementation of inter-laboratory rigor and reproducibility plans.

This program is informed by key priorities from the ADRD Summit 2025, including embracing ADRD complexity and breaking down topic- and disease-based silos, and is intended to provide a mechanistic foundation for future translational and clinical ADRD research.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with complementary expertise in ADRD mechanisms, clinical phenotypes, and advanced technologies are encouraged to contact agency staff listed below for additional information. 

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