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Centers without Walls for mechanisms of neurodegeneration in Alzheimer’s disease-related dementias (ADRD)

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Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institute of Neurological Disorders and Stroke (NINDS) plans to support collaborative research projects through a "Center without Walls" consortium focused on uncovering the mechanisms underlying neurodegeneration in Alzheimer’s disease-related dementias (ADRD). These consortia aim to integrate diverse expertise across institutions, utilizing interdisciplinary teams to address the complexity of ADRD, including co-pathologies, mixed etiologies, and disease heterogeneity. The research will leverage cutting-edge technologies, disease-relevant models, clinical data, and human specimens to identify new therapeutic targets, biomarkers, and factors influencing disease susceptibility and resilience. The program envisions funding that may utilize an activity code such as RM1 to enable robust interdisciplinary collaborations. One team will act as a coordinating center to facilitate communication, data sharing, and standardization across participating groups. This initiative aligns with priorities from the ADRD Summit 2025, emphasizing the need to break down disease silos and develop a mechanistic foundation for later translational and clinical research. While applications are not yet being solicited, interested investigators with relevant expertise are encouraged to contact NINDS ADRD staff to discuss potential collaborations and project ideas.

General Info

NINDS funds interdisciplinary consortium researching Alzheimer’s neurodegeneration mechanisms and therapeutic targets.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

Posted

forecast

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
NINDS ADRD Administration and Program Staff
contact@example.gov

Full Description

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The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting ambitious research projects to elucidate mechanisms of neurodegeneration in Alzheimer’s disease-related dementias (ADRD) organized as a “Center without Walls” consortium. NINDS Centers without Walls are collaborative research networks that bring together diverse expertise from different institutions to tackle complex neurological problems that are not tractable by individual research projects.

This program is considering using an activity code, such as the RM1, that enables interdisciplinary research consortia capable of identifying and characterizing novel ADRD mechanisms. Teams may include cross-disciplinary and cross-specialty expertise to address the complex co-pathologies, mixed etiologies, and disease heterogeneity in ADRD.

This program is anticipated to support teams that can combine multiple approaches, such as state-of-the-art technologies, disease-relevant models, clinical science, and human specimens, to investigate unique disease mechanisms and identify new therapeutic targets, biomarkers, and other factors influencing ADRD susceptibility, resilience, and pathology. One awardee team would serve as a coordinating center for all awardees to facilitate recurring meetings, data harmonization and sharing, cross-site communication, and support the implementation of inter-laboratory rigor and reproducibility plans.

This program is informed by key priorities from the ADRD Summit 2025, including embracing ADRD complexity and breaking down topic- and disease-based silos, and is intended to provide a mechanistic foundation for future translational and clinical ADRD research.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with complementary expertise in ADRD mechanisms, clinical phenotypes, and advanced technologies are encouraged to contact agency staff listed below for additional information. 

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