Clinical Data Ecosystem for Genomics (CDEG)
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The National Human Genome Research Institute within the National Institutes of Health is forecasting a funding opportunity to establish a Clinical Data Ecosystem for Genomics. This initiative aims to reduce barriers to the clinical integration and sharing of genome sequencing data and interpretations as structured data among patients, healthcare providers, and laboratories. The project will focus on creating a pilot ecosystem to demonstrate best practices for sharing genomic structured data, developing standardized application programming interfaces, and building open-source clinical software and databases. The goal is to ensure patient genomic data remains accessible as patients move across different healthcare systems and to develop implementation resources for widespread adoption. This opportunity, utilizing the U01 activity code, encourages collaborative applications from experts in computational genomics, data science, electronic health records, and health information exchange. While applications are not currently being accepted, this notice serves to allow potential applicants time to form the necessary collaborations for future submission.
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Full Description
The National Human Genome Research Institute (NHGRI) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research reduce barriers to a Clinical Data Ecosystem for Genomics (CDEG) by establishing a network to identify, share, and improve approaches for clinical integration and sharing of genome sequencing data and their interpretation as structured data among labs, health care providers, and patients. Specifically, the Network will: 1) establish a pilot ecosystem that demonstrates best practices for the sharing of genomic structured data (GSD) across different health care settings, including primary care; 2) create standardized application programming interfaces (APIs) to support access to such data; 3) develop open-source clinical software applications and databases that utilize these APIs; 4) demonstrate the ability of the pilot ecosystem to overcome barriers to accessing patient genomic data as patients travel across healthcare systems; and 5) refine and develop these practices into implementation resources for broader sharing and adoption. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of genomic medicine and implementation science are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in computational genomics and data science, electronic health records (EHR), genomic data standards, cloud and database development, health information exchange, and implementing genomics in clinical care will be encouraged and these investigators should also begin considering applying for this application.
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