Clinical Data Ecosystem for Genomics (CDEG)

The National Human Genome Research Institute (NHGRI) plans to issue a Notice of Funding Opportunity (NOFO) aimed at reducing barriers to the development of a Clinical Data Ecosystem for Genomics (CDEG). This initiative seeks to establish a network focused on identifying, sharing, and improving methods for the clinical integration and sharing of genome sequencing data and its structured interpretation across laboratories, healthcare providers, and patients. The project will involve creating a pilot ecosystem demonstrating best practices for sharing genomic structured data in diverse healthcare environments, including primary care, and the development of standardized APIs to facilitate data access. Additionally, it aims to produce open-source clinical software and databases utilizing these APIs, showcase the ecosystem’s ability to maintain patient genomic data access as individuals move across healthcare systems, and refine these processes into practical implementation resources for wider adoption. Although applications are not currently being accepted, this announcement provides advance notice to allow prospective applicants time to form collaborations and develop responses. The funding opportunity will use the U01 activity code and invites investigators with expertise in genomic medicine, implementation science, computational genomics, data science, electronic health records, genomic data standards, cloud/database development, health information exchange, and clinical genomics integration to consider applying. The program is managed by the NHGRI under the Department of Health and Human Services, with Jennifer Troyer serving as the point of contact. The goal is to foster multidisciplinary collaboration to overcome existing hurdles in clinical genomic data sharing, thereby enhancing patient care and data interoperability across healthcare settings.