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Establishing Pediatric CNS Pharmacodynamic Measures as Tools to Enable Psychiatric Indications in Adolescents

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Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institute of Mental Health, under the Department of Health and Human Services, is seeking research to optimize dosing strategies for new psychiatric medications in children and adolescents with serious mental illnesses. The primary objective is to develop and refine central nervous system tools and models, such as fMRI, EEG, digital health measures, and cognitive assessments, to determine how medications affect the young brain. By associating pharmacodynamic data with pharmacokinetic data, the initiative aims to enhance the safety and effectiveness of pediatric clinical trials. This forecast is intended to provide potential applicants time to establish collaborations before a formal solicitation is released. The agency encourages applications from experts in pediatric psychiatry, neuroimaging, clinical pharmacology, and clinical trials. Interested parties can contact Margaret C. Grabb for further information regarding this initiative.

General Info

NIMH seeks research on pediatric psychiatric medication dosing using neuroimaging, pharmacokinetics, pharmacodynamics.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
Margaret C. Grabb Ph.D
contact@example.gov
+1 (555) 000-0000

Full Description

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The National Institute of Mental Health (NIMH) seeks research that helps determine the best dosing strategies when testing new psychiatric medications in children and adolescents with serious mental illnesses.This NOFO will focus on developing and refining central nervous system (CNS) tools and models that can show how medications affect the brain in young people. These tools might include functional brain imaging methods like EEG or fMRI, as well as digital health measures or cognitive assessments. Studies are encouraged that explore how dosing impacts drug exposure (pharmacokinetics) and related CNS functional effects (pharmacodynamics). The overall goal is to improve the safety and effectiveness of pediatric clinical trials by developing pediatric pharmacodynamic measures, to associate pharmacodynamic data with pharmacokinetic data, and to establish associated models. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Researchers with expertise in pediatric psychiatry, neuroimaging, pediatric clinical pharmacology, clinical trials, or related fields are encouraged to consider applying to the new NOFO.

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