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Exposomic Contributions to ADRD Pathology and Resilience

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Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institute of Neurological Disorders and Stroke is seeking research projects to investigate how neural exposome factors, such as environmental toxins, stress, and sleep patterns, mechanistically contribute to Alzheimer’s disease-related dementias pathology and resilience. The program emphasizes the synergistic effects of multiple exposome factors and encourages a focus on mechanistic pathways like neuroimmune signaling, epigenetic modifications, and microbiome-brain interactions. Research may span the entire lifespan, including studies on sensitive exposure periods and factors contributing to neurological health disparities. Eligible projects may include mechanistic, translational, and human subjects research utilizing clinical data and observational or interventional studies, though NIH-defined clinical trials are excluded. This forecast is intended to allow potential applicants to establish collaborations across expertise in exposomics, environmental neuroscience, and community engagement. The initiative is managed by the National Institutes of Health under the Department of Health and Human Services.

General Info

NINDS supports research on neural exposome factors affecting Alzheimer's disease mechanisms and health disparities.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
contact@example.gov

Full Description

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The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting research projects that investigate how specific neural exposome factors contribute mechanistically to Alzheimer’s disease-related dementias (ADRD) pathology and resilience. For the purposes of this program, exposome factors of interest include, but are not limited to, environmental toxins, sleep and circadian rhythms, stress, and the real-world conditions that modulate them (e.g., light, noise, heat).

Applications will be expected to propose research on the synergistic action between multiple exposome factors, and the composite effects of mixtures of exposome factors on neural mechanisms relevant to ADRD. Applicants are encouraged to focus on mechanistic pathways (e.g., microbiome–brain interactions, neuroimmune signaling, epigenetic modifications) that link exposures to ADRD risk, progression, and resilience. Applicants are further encouraged to consider studies that cover the lifespan, including work that investigates critical or sensitive periods of exposure or factors that may lead to neurological health disparities. Applicants may propose mechanistic, translational, and/or human subjects research, drawing on clinical data, human samples, and observational or interventional studies. However, NIH-defined clinical trials will not be supported under this program.

Applications are not currently being solicited. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigative teams with expertise in exposomics and environmental neuroscience, community engagement, ADRD mechanisms, and non-medical factors that may lead to health disparities are encouraged to apply.

 

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