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Exposomic Contributions to ADRD Pathology and Resilience

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Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institute of Neurological Disorders and Stroke (NINDS) is preparing to support research focused on how various neural exposome factors, such as environmental toxins, sleep patterns, stress, and related real-world conditions, contribute to the development and resilience of Alzheimer’s disease-related dementias (ADRD). Researchers are encouraged to explore the combined effects of multiple exposome factors and their impact on neural mechanisms linked to ADRD risk and progression. Emphasis is placed on mechanistic studies involving pathways like microbiome-brain interactions, neuroimmune signaling, and epigenetic changes, with a focus on lifespan exposures and factors that may contribute to neurological health disparities. While applications are not currently being solicited, this notice aims to provide prospective applicants ample time to form collaborative and responsive research projects. Studies can encompass mechanistic, translational, and human subjects research using clinical data and observational or interventional approaches, although traditional clinical trials will not be funded. Ideal research teams will have expertise in exposomics, environmental neuroscience, community engagement, ADRD mechanisms, and non-medical determinants of health disparities. The funding opportunity is administered through the Department of Health and Human Services via the National Institutes of Health.

General Info

NINDS supports research on neural exposome factors affecting Alzheimer's disease mechanisms and health disparities.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

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forecast

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
contact@example.gov

Full Description

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The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting research projects that investigate how specific neural exposome factors contribute mechanistically to Alzheimer’s disease-related dementias (ADRD) pathology and resilience. For the purposes of this program, exposome factors of interest include, but are not limited to, environmental toxins, sleep and circadian rhythms, stress, and the real-world conditions that modulate them (e.g., light, noise, heat).

Applications will be expected to propose research on the synergistic action between multiple exposome factors, and the composite effects of mixtures of exposome factors on neural mechanisms relevant to ADRD. Applicants are encouraged to focus on mechanistic pathways (e.g., microbiome–brain interactions, neuroimmune signaling, epigenetic modifications) that link exposures to ADRD risk, progression, and resilience. Applicants are further encouraged to consider studies that cover the lifespan, including work that investigates critical or sensitive periods of exposure or factors that may lead to neurological health disparities. Applicants may propose mechanistic, translational, and/or human subjects research, drawing on clinical data, human samples, and observational or interventional studies. However, NIH-defined clinical trials will not be supported under this program.

Applications are not currently being solicited. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigative teams with expertise in exposomics and environmental neuroscience, community engagement, ADRD mechanisms, and non-medical factors that may lead to health disparities are encouraged to apply.

 

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