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Forecast to Publish a Funding Opportunity Announcement for Copy of Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia Administrative Resource Core (U24) (Clinical Trial Optional)

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The contract relates to the renewal of the NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA), aiming to support two collaborative research consortia focused on understanding brain-body homeostatic dysregulation that drives excessive alcohol consumption and associated Alcohol Use Disorder (AUD) phenotypes. The initiative encourages hypothesis-driven studies examining interactions between alcohol and other causative factors, with an emphasis on the progression from initial alcohol exposure to the development of harmful drinking behaviors. Researchers are expected to utilize and adapt cutting-edge technologies from major NIH initiatives to study brain structure and function across multiple biological scales, and to investigate peripheral influences impacting these processes. The program promotes standardization and replication to ensure rigor and reproducibility, encouraging integration across projects, sites, and species. This renewal will fund two multisite consortia using cooperative agreements, each consisting of administrative and resource cores alongside individual research projects funded through U01 mechanisms. Although applications are not currently being solicited, this forecast is intended to alert potential investigators to begin forming collaborations and developing projects aligned with the initiative’s goals. The funding opportunity will employ the U24 activity code, and those with expertise in integrative neuroscience related to alcoholism are encouraged to prepare for the upcoming solicitation. The initiative is managed by the National Institutes of Health under the Department of Health and Human Services, with contact information provided for further inquiries.

General Info

Renewal funds two consortia studying brain-body dysregulation driving Alcohol Use Disorder, using advanced technologies.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

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forecast

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
Mark Egli
contact@example.gov
+1 (555) 000-0000

Full Description

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The purpose is to renew the NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA). The INIA renewal will support two collaborative research consortia through an open competition to study brain-body homeostatic dysregulation that promotes and perpetuates excessive alcohol drinking and related Alcohol Use Disorder (AUD) phenotypes. We encourage hypothesis-centered research on interactions between alcohol and other relevant causal influences. Focus on trajectories from initial alcohol exposure to the development of pathological drinking by some individuals will identify translatable markers and mechanisms to support future prevention and intervention efforts that reduce the chronic conditions associated with alcohol misuse including but not limited to AUD. To promote innovation, investigators will adapt advanced tools and technologies from the BRAIN Initiative, NIH Common Fund, and other sources to examine brain structure and function at multiple spatial and temporal scales, from microcircuitry to whole brain networks, and reveal peripheral influences on brain function underlying excessive alcohol drinking. To promote rigor and reproducibility, a focus on standardization of neurofunctional measures and replication will be instituted across both consortia. In the context of the initiative, integration occurs with: (1) projects across multiple participating sites addressing objectives around a central hypothesis, (2) knowledge of actions and interactions at multiple biological scales of analysis, (3) shared resources and standardized experimental protocols, and (4) cross-species translation. The initiative renewal will support two collaborating multisite consortia though cooperative agreement mechanisms, each comprised of administrative and resource cores, and U01s for individual research projects. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of integrative neuroscience are encouraged to begin to consider applying for this new NOFO. 

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