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Forecast to Publish a Funding Opportunity Announcement for Copy of Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia Research Resource (U24) (Clinical Trial Optional)

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The National Institutes of Health plans to renew the Integrative Neuroscience Initiative on Alcoholism (INIA) to support collaborative research focused on understanding brain-body homeostatic disruptions that contribute to excessive alcohol drinking and Alcohol Use Disorder (AUD). This renewal will fund two multisite consortia through cooperative agreements, emphasizing hypothesis-driven studies on how alcohol interacts with other causal factors over the course of drinking trajectories, from initial exposure to the onset of pathological use. The initiative aims to identify translatable biological markers and mechanisms to facilitate the development of prevention and intervention strategies targeting chronic alcohol-related conditions. The research will leverage advanced technologies and tools from prominent initiatives like the BRAIN Initiative and the NIH Common Fund to examine brain function across multiple scales, from microcircuits to whole-brain networks, while also investigating peripheral influences on brain activity. A major emphasis is placed on standardization and replication to ensure rigor and reproducibility across the consortia. Collaboration and integration are key, involving shared resources, standardized protocols, and cross-species translation. Although applications are not yet being solicited, this forecast notice allows potential investigators to prepare for the upcoming funding opportunity, which will utilize the U24 activity code and support both administrative cores and individual research projects within the consortia.

General Info

NIH renews INIA to fund multisite research on brain-alcohol interactions, biomarkers, prevention, and intervention.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

Posted

forecast

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
Mark Egli
contact@example.gov
+1 (555) 000-0000

Full Description

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The purpose is to renew the NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA). The INIA renewal will support two collaborative research consortia through an open competition to study brain-body homeostatic dysregulation that promotes and perpetuates excessive alcohol drinking and related Alcohol Use Disorder (AUD) phenotypes. We encourage hypothesis-centered research on interactions between alcohol and other relevant causal influences. Focus on trajectories from initial alcohol exposure to the development of pathological drinking by some individuals will identify translatable markers and mechanisms to support future prevention and intervention efforts that reduce the chronic conditions associated with alcohol misuse including but not limited to AUD. To promote innovation, investigators will adapt advanced tools and technologies from the BRAIN Initiative, NIH Common Fund, and other sources to examine brain structure and function at multiple spatial and temporal scales, from microcircuitry to whole brain networks, and reveal peripheral influences on brain function underlying excessive alcohol drinking. To promote rigor and reproducibility, a focus on standardization of neurofunctional measures and replication will be instituted across both consortia. In the context of the initiative, integration occurs with: (1) projects across multiple participating sites addressing objectives around a central hypothesis, (2) knowledge of actions and interactions at multiple biological scales of analysis, (3) shared resources and standardized experimental protocols, and (4) cross-species translation. The initiative renewal will support two collaborating multisite consortia though cooperative agreement mechanisms, each comprised of administrative and resource cores, and U01s for individual research projects. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of integrative neuroscience are encouraged to begin to consider applying for this new NOFO.

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