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Forecast to Publish a Funding Opportunity Announcement for Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia (U01 Clinical Trial Optional)

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Contract Overview

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The contract pertains to the renewal of the NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA), which aims to support two collaborative research consortia focusing on brain-body homeostatic dysregulation that drives excessive alcohol consumption and Alcohol Use Disorder (AUD). This initiative emphasizes hypothesis-driven research exploring the interactions between alcohol and various causal factors, with a particular focus on the progression from initial alcohol exposure to pathological drinking behaviors. The goal is to identify translatable markers and mechanisms to inform future prevention and intervention strategies for chronic alcohol-related conditions. The renewal encourages the use of advanced tools and technologies from sources such as the BRAIN Initiative to study brain structure and function across multiple scales, as well as peripheral influences on brain function, while emphasizing rigor, reproducibility, standardization of neurofunctional measures, and replication efforts across the consortia. The INIA renewal will support two multisite consortia through cooperative agreements, each containing administrative and resource cores alongside individual research project awards under the U01 activity code. These consortia will facilitate integration across multiple sites, biological scales, shared resources, standardized protocols, and cross-species translation. While applications are not currently being solicited, this announcement serves to alert potential applicants so they may begin forming collaborations and developing responsive projects. The initiative is overseen by the National Institutes of Health within the Department of Health and Human Services, with key contact provided for further inquiries.

General Info

Renewal supports two consortia researching brain-body mechanisms driving excessive alcohol use and AUD.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

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forecast

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
Mark Egli
contact@example.gov
+1 (555) 000-0000

Full Description

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The purpose is to renew the NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA). The INIA renewal will support two collaborative research consortia through an open competition to study brain-body homeostatic dysregulation that promotes and perpetuates excessive alcohol drinking and related Alcohol Use Disorder (AUD) phenotypes. We encourage hypothesis-centered research on interactions between alcohol and other relevant causal influences. Focus on trajectories from initial alcohol exposure to the development of pathological drinking by some individuals will identify translatable markers and mechanisms to support future prevention and intervention efforts that reduce the chronic conditions associated with alcohol misuse including but not limited to AUD. To promote innovation, investigators will adapt advanced tools and technologies from the BRAIN Initiative, NIH Common Fund, and other sources to examine brain structure and function at multiple spatial and temporal scales, from microcircuitry to whole brain networks, and reveal peripheral influences on brain function underlying excessive alcohol drinking. To promote rigor and reproducibility, a focus on standardization of neurofunctional measures and replication will be instituted across both consortia. In the context of the initiative, integration occurs with: (1) projects across multiple participating sites addressing objectives around a central hypothesis, (2) knowledge of actions and interactions at multiple biological scales of analysis, (3) shared resources and standardized experimental protocols, and (4) cross-species translation. The initiative renewal will support two collaborating multisite consortia though cooperative agreement mechanisms, each comprised of administrative and resource cores, and U01s for individual research projects. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01activity code. Investigators with expertise and insights into this area of integrative neuroscience are encouraged to begin to consider applying for this new NOFO.

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