Forecast to Publish a Funding Opportunity Announcement for Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Research Project Sites (U01 Clinical Trials Optional)
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The National Institutes of Health, through the National Institute on Alcohol Abuse and Alcoholism, is forecasting a limited competition funding opportunity for the continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence. This project utilizes an accelerated longitudinal design to study how adolescent alcohol consumption disrupts brain growth, function, and psychiatric health as individuals transition into emerging adulthood. By tracking a cohort of over 800 individuals, the research aims to determine the long-term effects of early versus late onset drinking on adult behavior and brain function. The renewal of this U01 activity code project will allow the consortium to follow participants up to 37 years of age. The primary goal is to generate data necessary for developing evidence-based prevention strategies and early intervention approaches to reduce the progression of alcohol use disorders and chronic disease. While applications are not currently being solicited, this notice serves to allow investigators with expertise in developmental neuroscience to establish collaborations and prepare responsive projects.
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The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of developmental neuroscience are encouraged to begin to consider applying for this new NOFO.
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