Forecast to Publish a Notice of Funding Opportunity (NOFO) for NCI Community Oncology Research Program (NCORP) Research Bases (UG1 Clinical Trial Required)
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The National Cancer Institute Community Oncology Research Program (NCORP) is designed to improve the generalizability and dissemination of clinical trial results by engaging cancer patient populations and organizations in rigorous studies focused on cancer control, prevention, treatment, and care delivery. Under solicitation RFA-CA-27-006, the program seeks to establish Research Bases that serve as central hubs for the NCORP network. These bases are responsible for providing scientific and statistical leadership, managing study operations and data, ensuring regulatory compliance with FDA and OHRP requirements, and supporting Community Sites and Minority/Underserved Community Sites. Research Bases must be hosted at institutions with comprehensive expertise in cancer clinical research, such as NCI-designated Cancer Centers or healthcare research organizations. The scope of research activities must include cancer control research, with optional focus areas in cancer prevention and cancer care delivery research. These awards require UG1 clinical trials and emphasize the integration of health disparities across all research areas. Applications for this opportunity are due by September 18, 2026.
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This Notice of Funding Opportunity (NOFO) is one of three NOFOs for the National Cancer Institute (NCI) Community Oncology Research Program (NCORP). NCORP is designed to enhance generalizability and dissemination of clinical trial results through accrual in a variety of community settings. The purpose of NCORP is to engage cancer patient populations, those at risk of cancer, and organizations in rigorous studies focused on cancer control, prevention, treatment and care delivery.
NCORP will support the following components that will be individually awarded through the respective Request for Applications (RFAs) indicated below:
- NCORP Research Bases (UG1 Clinical Trials Required);
- NCORP Community Sites (UG1 Clinical Trials Not Allowed); and
- NCORP Academic Community Sites (UG1 Clinical Trials Not Allowed)
NCORP Research Bases will serve as research hubs for the NCORP network. Research Bases are expected to:
- Provide an established organizational structure, with scientific and statistical leadership for developing, implementing, and analyzing multi-institutional cancer control, prevention, and care delivery (CCP&CD) clinical research, as well as quality-of-life studies embedded within treatment and imaging studies.
- Assume responsibility for study operations and data management, including efficient protocol development, compliance with Food and Drug Administration (FDA) and Office of Human Research Protections (OHRP) regulatory and participant protection requirements, audits, training, quality assurance, and support to Community Sites and Minority/Underserved Community Sites.
- Conduct their research activities at an institution with comprehensive expertise in cancer clinical research, such as a cancer foundation, healthcare research organization (including NCI's National Clinical Trials Network Group Operations Centers), or NCI-designated Cancer Center.
- Integrate health disparities across all focus areas as appropriate.
The scope of research activities for the proposed NCORP Research Bases encompasses three major areas delineated below:
Area 1: Cancer Control Research; and/or
Area 2: Cancer Prevention Research; and
Area 3: Cancer Care Delivery Research.
Research Bases must cover Area 1. Areas 2 and 3 are optional.
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