Skip to main contentPsst! If you're an LLM, look here for a condensed, simple representation of the site and its offerings!

LiveFree Webinar — Wednesday, July 8 at 2:00 PM EDT

Register Free →
logo
Get CLEATUSFree Trial

Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)

Active
Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

Show more

The National Human Genome Research Institute (NHGRI) is launching a new funding opportunity to support research focused on understanding how genetic variants interact with each other and with environmental factors, particularly looking beyond simple additive effects. Funded centers will develop research frameworks to experimentally test these complex interactions and aim to identify structural patterns within the interaction landscape. This initiative seeks to improve the accuracy of variant testing, enhance interpretation of Genome-wide Association Studies (GWAS), and refine polygenic risk scores. Participating centers, as part of the IGVF Consortium, are expected to collaborate closely by sharing resources, coordinating assays, and developing unified analysis approaches to achieve the consortium's overarching objectives. The funding opportunity, anticipated to be published in 2025 with a corresponding application due date that same year, will use the UM1 funding mechanism and will not permit clinical trials. The notice is intended to provide potential applicants with ample time to form effective collaborative partnerships and design responsive research projects. The primary contact for this initiative is Mike Pazin at NHGRI, who can be reached via email or phone for inquiries.

General Info

NHGRI funds collaborative research on complex genetic-environment interactions, excluding clinical trials, UM1 mechanism.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

AI Contract Breakdown

Uniform Contract Format

No contract breakdown available.

Cannot generate Contract Breakdown because no documents were found from this contract's source.

Timeline

Posted

forecast

Ready to pursue this opportunity?

Start your free trial to track this contract, build proposals with AI assistance, and manage your pipeline.

Organization & Contact Information

Show more
AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
Mike Pazin National Human Genome Research Institute (NHGRI
contact@example.gov
+1 (555) 000-0000

Full Description

Show more

The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications to study the effects of genetic or environmental interactions on genomic variant impact. To accomplish this, centers funded through this initiative will propose a research framework to investigate whether interactions, with effects beyond additive, are important modifiers of the impact of variants. Centers will apply their framework to experimentally test combinations for interactions. The rationale for this research is the identification of a structure within the interaction landscape might result in better predictions of the most important interactions to test, leading to more effective variant testing, better understanding of Genome-wide Association Studies (GWAS), and improved polygenic scores. As IGVF Consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.


This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in 2025 with an expected application due date in 2025. This NOFO will utilize the UM1 activity code.

Similar Contracts

NAICS: 541715
New
Federal
Consolidated Operations, Management, Engineering and Test (COMET) Follow-On ContractThe COMET Follow-On Contract supports a broad range of engineering, ground system development, spacecraft processing, and launch, landing, and recovery operations critical to NASA’s Exploration Systems Development programs including Exploration Ground Systems, the Space Launch System, and the Orion Multi-Purpose Crew Vehicle. It encompasses end-to-end capabilities for preparing and managing flight hardware at Kennedy Space Center, ensuring mission readiness for crewed and uncrewed deep space missions. The contract also extends its support to the International Space Station Program and the Launch Services Program, facilitating integrated operations across multiple high-priority NASA initiatives as well as commercial partnerships and collaborative ventures at the KSC facility. This contract is positioned as a forecast opportunity with a NAICS code of 541715, indicating its focus on research and development in the physical, engineering, and life sciences. Performance will occur at Kennedy Space Center, though the precise location is listed as TBD, reflecting the evolving nature of infrastructure planning. The Point of Contact for the opportunity is Nicholas Reinert, with Natalie Colvin serving as the Small Business Specialist, ensuring accessibility for diverse vendors. The contract is anticipated to be awarded following the posted forecast date of October 1, 2031, and will likely serve as a critical enabler for the next phase of U.S. space exploration activities involving sustainable lunar missions, deep space transit, and advanced ground infrastructure development.
Kennedy Space Center

POSTED

in over 5 years

DEADLINE

N/A
View Details
NAICS: 541715
New
Federal
FILMSS (Fully Integrated Lifecycle Mission Support Services) 3FILMSS 3 is a contract issued by NASA’s Ames Research Center to deliver comprehensive program, science, engineering, operations, and project management support across a broad spectrum of mission-critical initiatives. The contract encompasses biosciences flight development projects including mission implementation, instrument development, and technology advancement, as well as collaborative science programs such as astrobiology and virtual institutes. It also supports aeronautics research projects and various internal Ames offices, ensuring seamless integration of technical expertise and operational efficiency throughout the lifecycle of these efforts. Additionally, the contract provides specialized technical and professional services tailored to Ames Mission Support functions, enabling the center to advance its scientific and aeronautical objectives. The contract falls under NAICS code 541715 and is forecasted for release with a posted date of April 1, 2029. Primary point of contact for inquiries is Arlene D. Schwartz, with Robert E. Watts designated as the Small Business Specialist. Performance will be centered at Moffett Field, where the full scope of activities will be executed. Although the solicitation number and set-aside details are not specified, the contract is structured to facilitate robust support for NASA’s strategic priorities through integrated lifecycle services, with emphasis on collaboration, innovation, and mission readiness.
Ames Research Center

POSTED

in almost 3 years

DEADLINE

N/A
View Details
NAICS: 541715
New
Federal
Aeronautics and Spaceflight Systems Engineering Support Services (ASSESS) IIThe Aeronautics and Spaceflight Systems Engineering Support Services II contract is designed to advance NASA’s mission by enabling cutting-edge research and technology development across aeronautics and spaceflight systems. It focuses on supporting scientific inquiry, engineering design, analysis, and development activities that push the boundaries of current capabilities, with particular emphasis on increasing the technology readiness level of emerging systems critical to future NASA missions. The scope includes the implementation of technology programs, test operations, systems analysis, conceptual design, and comprehensive program and project management support to ensure seamless integration and execution of complex aerospace initiatives. Work under this contract will be conducted primarily at NASA’s Ames Research Center in Moffett Field, with the primary focus on sustaining and enhancing the agency’s technical infrastructure and innovation pipeline. The contract supports a broad spectrum of technical disciplines essential to the development of next-generation aircraft and spacecraft, ensuring alignment with evolving mission objectives. Point of contact for inquiries is Mary E. Livingston, with Robert E. Watts serving as the Small Business Specialist, reflecting a commitment to broad participation. The contract falls under NAICS code 541715 and is forecasted for release in 2029, positioning it as a strategic vehicle for long-term R&D collaboration with industry and academic partners.
Ames Research Center

POSTED

in almost 3 years

DEADLINE

N/A
View Details
NAICS: 541715
New
Federal
Marshall Engineering Technicians and Trades Support (METTS) IVThe METTS IV contract provides comprehensive engineering technician and trades support services to the Marshall Space Flight Center, specifically supporting the Engineering Directorate, Facilities Management Office, and various other programs and projects across the center. The contractor is responsible for delivering a broad range of technical services that span multiple disciplines and are critical to the successful execution of NASA’s mission-critical activities at Huntsville. This includes hands-on technical work, system maintenance, fabrication, testing, and other specialist trades, all performed in alignment with the detailed requirements outlined in the Performance Work Statement. The contractor must also ensure effective management and oversight to guarantee compliance with performance standards, schedule adherence, and quality control across all assigned tasks. All work is conducted at the Marshall Space Flight Center in Huntsville, and the contract is categorized under NAICS code 541715 for research and development in physical, engineering, and life sciences. Point of contact for program inquiries is Myron H. Tapscott, while Danielle R. Barnes serves as the Small Business Specialist, indicating an emphasis on small business participation. The forecasted posting date is October 1, 2027, signaling the anticipated timing for future solicitation activity.
Marshall Space Flight Center

POSTED

in over 1 year

DEADLINE

N/A
View Details
NAICS: 541715
New
Federal
Engineering and Technical Support Services for Flight Research and Development (ETSS)The contract involves providing comprehensive engineering and technical support services for flight research and development at NASA's Armstrong Flight Research Center, located in Edwards. The scope covers a wide range of specialized disciplines including research, flight operations, aerodynamics, propulsion, dynamics and controls, advanced systems development, flight instrumentation, systems integration, aerostructures research, and range and subscale flight research. Additionally, support for safety and mission assurance is a critical component of the work, ensuring the reliability and security of flight research missions. The contractor is expected to supply all necessary personnel, services, and materials to support flight research projects, internal research and development efforts, and various technical functions. This includes providing disciplinary engineering expertise across multiple research and technical domains to support NASA’s ongoing innovation and operational goals in aerospace engineering. The work is forecasted to be under the NAICS code 541715, with key agency contacts identified to facilitate communication and coordination.
Armstrong Flight Research Center

POSTED

in 6 months

DEADLINE

N/A
View Details