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Glioblastoma Therapeutics Network (GTN; U19 Clinical Trial Required)

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Grant

Contract Overview

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AI Contract Overview

The National Cancer Institute is seeking applications to establish the Glioblastoma Therapeutics Network to develop and test novel therapies for adult glioblastoma. The primary objective is to create effective agents capable of crossing the blood brain barrier, focusing on both entirely new agents and repurposed drugs approved for other indications. This initiative aims to bridge the gap in drug development by supporting the transition from late pre-clinical research through Investigational New Drug studies and into Phase 0 or 1 clinical trials. This forecasted opportunity, managed by the National Institutes of Health under the Department of Health and Human Services, requires a highly collaborative approach using cross-cutting teams. Successful early-stage trials resulting from this network are intended to transition into later-stage clinical trials via established NCI mechanisms. Interested parties can find further details through the grants.gov portal or by contacting the designated point of contact, Suzanne Forry.

General Info

NCI funds collaborative GBM research to develop and clinically test blood-brain barrier-crossing therapies.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

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Timeline

PostedSep 17

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health

Contacts1 person available

OfficeUSA

Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health

Office AddressUSA

Contacts

Suzanne Forry Ph.D

contact@example.gov

+1 (555) 000-0000

Full Description

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically. Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms.

To implement this concept, a highly collaborative GBM Therapeutics Network (GTN) of cross-cutting teams will be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through IND studies, into pilot clinical studies in humans. Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process.