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Illuminating AD/ADRD Genome to Enable Precision Genomic Medicine

Active
Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institute on Aging plans to issue a funding opportunity to support interdisciplinary research projects focused on advancing mechanistic studies of Alzheimer’s disease and related dementias (AD/ADRD) through genomic investigations. These projects aim to utilize innovative approaches such as machine learning, comparative genomic analyses across diverse genetic ancestries and neurodegenerative diseases, genome editing, functional assays, and state-of-the-art single-cell and spatial omics techniques. Studies will be conducted using advanced disease models including human stem cell-derived systems, ex vivo and in vivo platforms that represent various genetic backgrounds and species, allowing for a comprehensive exploration of genomic drivers underlying neurodegeneration and disease progression. The initiative seeks to foster cross-disciplinary collaborations that can generate precise mechanistic insights, ultimately identifying actionable therapeutic targets to guide precision medicine interventions for AD/ADRD. While applications are not currently being solicited, this advance notice aims to provide researchers sufficient time to develop partnerships and design responsive projects. The funding will be offered through a U01 cooperative agreement mechanism, and investigators with expertise in this area of aging research are encouraged to prepare for forthcoming solicitations. For further inquiries, contact Dr. Alison Yao at the National Institute on Aging.

General Info

Funding for interdisciplinary genomic research on Alzheimer’s disease mechanisms using advanced models and techniques.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

Posted

forecast

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
Alison Yao Ph.D
contact@example.gov
+1 (555) 000-0000

Full Description

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The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications that propose a program that supports integrative, cross-disciplinary projects aimed at scaling up mechanistic studies to understand the genomic underpinnings of the pathogenesis and progression AD/ADRD.

The proposed research projects will employ interdisciplinary approaches that integrate innovative techniques to dissect the genomic drivers of AD/ADRD. These projects will leverage advanced analytical methods, including machine learning and comparative genomic analysis across multiple genetic ancestries or multiple neurodegenerative diseases, along with cutting-edge tools like genome editing, functional characterization assays, and emerging single-cell and spatial omics technologies. These studies will use sophisticated disease models, such as human stem cell-based systems, ex vivo, and in vivo models that reflect different genetic ancestries, various model organisms, or multiple neurodegenerative conditions. These cross-ancestry, cross-disease, and cross-species approaches will enable a more comprehensive investigation of the genomic drivers of neurodegeneration and neuropathogenesis. Ultimately, this initiative may lead to the identification of actionable therapeutic targets for AD/ADRD, meeting the urgent need for mechanism-driven insights that can guide precision medicine approaches for its treatment.

Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO intends to utilize the U01 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.

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