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Impact of Immunotherapies on CNS Outcomes in People with HIV: Potential Benefits, Challenges and Risks

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Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

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The National Institute of Mental Health is issuing a forecast for a biphasic research opportunity using the R21/R33 activity code to evaluate how HIV immunotherapies affect central nervous system outcomes. The primary objective is to determine if these therapies can safely target HIV persistence in the CNS while reducing neuroinflammation and neurotoxicity. This research will specifically focus on overcoming challenges such as blood brain barrier penetration and compartmentalized viral dynamics to improve long term cognitive and neurologic health for people living with HIV. Managed by the Department of Health and Human Services under the National Institutes of Health, this initiative seeks investigators with specialized expertise in viral reservoirs and CNS impacts. The funding opportunity is designed to generate evidence for achieving sustained virologic remission across all anatomical compartments. Interested parties are encouraged to establish collaborations in preparation for the formal notice of funding opportunity.

General Info

NIMH funds biphasic research on HIV immunotherapies targeting CNS outcomes, neurotoxicity, and viral remission.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

Posted

forecast

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
Division of AIDS Research
contact@example.gov

Full Description

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The National Institute of Mental Health (NIMH) intends to publish a notice of funding opportunity (NOFO) to solicit biphasic research applications to evaluate the impact of HIV immunotherapies on central nervous system (CNS) outcomes in people with HIV and to identify mechanisms, benefits, and risks associated with their use in the CNS compartment. The primary goal is to generate evidence that informs whether HIV immunotherapies can safely and effectively target CNS HIV persistence while minimizing neurotoxicity and neuroinflammation. By addressing CNS-specific barriers such as blood brain barrier penetration, compartmentalized viral dynamics, and immune-mediated effects, this NOFO will support the development of strategies that contribute to sustained virologic remission across anatomical compartments and improve long-term neurologic and cognitive outcomes in people with HIV. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into the impact of HIV immunotherapies on the CNS and viral reservoirs are strongly encouraged to apply to this new NOFO. This NOFO will utilize the R21/R33 activity code.

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