Interdisciplinary Research to Understand the Complex Biology of Resilience to Alzheimer’s and Related Dementias Disease Risk
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The National Institute on Aging is planning a Notice of Funding Opportunity to support interdisciplinary research focused on the molecular mechanisms of resilience against Alzheimer's disease and related dementias. This initiative aims to integrate genomic, epidemiologic, and mechanistic research using systems-based approaches, including artificial intelligence and machine learning, to identify cellular determinants of resilience across diverse populations. The program will prioritize the generation of high-dimensional molecular data from peripheral tissues and the brain, including longitudinal data, to facilitate dynamic modeling and the discovery of molecular predictors. This forecast is intended to provide potential applicants time to establish collaborations before the official solicitation is released. The funding will utilize the U01 activity code and is managed by the National Institutes of Health under the Department of Health and Human Services. Interested investigators with expertise in aging research are encouraged to prepare responsive projects for this upcoming opportunity.
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Full Description
The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) that builds upon its investment in data-driven approaches for the purpose of defining molecular mechanisms of resilience in the presence of various types of Alzheimer's disease (AD) and AD-related dementias (ADRD) risk. The goal of this NOFO is to build a robust program that integrates epidemiologic, genomic, and mechanistic research through the use of data driven, systems-based approaches (including the use of artificial intelligence and/or machine learning methods) to discover the molecular/cellular determinants of resilience to AD/ADRD risk across representative populations. The initiative will support the generation of high-dimensional molecular data from brain and peripheral tissues, including longitudinal data, to enable dynamic modeling of resilience mechanisms and to discover molecular predictors of resilience.
Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO intends to utilize the U01 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.
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