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Limited Competition: Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium- Field Epidemiology Sites

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Contract Overview

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AI Contract Overview

The National Institutes of Health is seeking renewal applications for Field Epidemiology Sites as part of the Consortium to Study Chronic Kidney Disease of UnceRtain Etiology in Agricultural Communities. This joint effort by NIDDK, NIEHS, and FIC aims to investigate the causes and potential interventions for CKDu, a condition causing kidney failure in young working populations within rural areas of low and middle income countries. By studying environmental factors and genetic susceptibility, the research seeks to provide insights into tubulointerstitial renal diseases that are also relevant to patients in the United States. Selected Field Epidemiology Sites will be responsible for identifying, recruiting, and retaining participants in endemic areas, conducting study visits, and collecting biological and environmental samples. These sites will work alongside a Renal and Environmental Science Core and a Data Coordinating Center to identify therapeutic targets and public health interventions. This is a limited competition forecast where applications will undergo peer review to determine funding based on merit.

General Info

Renewal funding for epidemiology sites researching CKDu causes, exposures, and interventions in agricultural communities.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

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Timeline

PostedSep 30

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health

Contacts1 person available

OfficeUSA

Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health

Office AddressUSA

Contacts

Susan Mendley

contact@example.gov

+1 (555) 000-0000

Full Description

The purpose of this funding opportunity is to advance the NIH mission by supporting the continuation of the Consortium to Study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE).

Chronic Kidney Disease of Uncertain Etiology (CKDu) causes kidney failure in rural areas of many Low and Middle Income Countries, resulting in a large death toll among the young working age population. Environmental factors are suspected to be causative, but family and geographic clustering add consideration of unrecognized genetic susceptibility. The risk factors identified in other countries are encountered by U.S. patients, so this research will offer valuable insights into the development and progression of tubulointerstitial renal diseases, with broad implications for understanding kidney health and disease in the U.S.

NIDDK, NIEHS, and FIC have jointly funded a consortium that includes Field Epidemiology Sites, a Renal and Environmental Science Core, and a Data Coordinating Center to find causes and potential interventions for CKDu since 2021. This NOFO requests renewal applications for the Field Epidemiology Sites that will continue to identify, recruit, and retain participants in CKDu endemic areas, conduct study visits, and collect biological and environmental samples. Consortium members will continue to collaborate to maximize scientific opportunities and enable discovery science to understand the etiologies of CKDu, the exposures that initiate and affect progression of tubulointerstitial kidney disease, potential therapeutic targets, and future opportunities for public health interventions. The CURE Consortium will serve as a resource for ancillary studies.

This is a forecast for a limited competition Notice of Funding Opportunity (NOFO) that will invite application(s) from eligible organizations to apply. Application(s) will be peer-reviewed and only funded if meritorious.