Limited Competition: Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium- Field Epidemiology Sites
Contract Overview
Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.
AI Contract Overview
This contract supports the continuation of the Consortium to Study Chronic Kidney Disease of Uncertain Etiology (CKDu) in Agricultural Communities (CURE), aiming to further the NIH mission by investigating this disease primarily affecting rural, low- and middle-income countries. CKDu, a condition leading to kidney failure with unclear causes, disproportionately impacts young working-age individuals in agricultural settings. Environmental and potential genetic factors are being studied to better understand the disease's origins and progression. The research efforts have relevance to U.S. populations as well, as similar risk factors are present domestically, offering opportunities to improve knowledge of kidney diseases broadly. Funded jointly by NIDDK, NIEHS, and FIC since 2021, the consortium includes Field Epidemiology Sites, a Renal and Environmental Science Core, and a Data Coordinating Center. This funding opportunity requests renewal applications specifically for the Field Epidemiology Sites responsible for participant recruitment, study visits, and sample collection in CKDu-affected areas. The consortium promotes collaboration to deepen scientific understanding of CKDu’s causes, identify exposures involved in disease onset and progression, discover therapeutic targets, and pave the way for public health interventions. This limited competition NOFO invites eligible organizations to submit peer-reviewed applications, which will be funded based on merit.
General Info
Agency
NAICS
Place of Performance
Not specifiedSet-Aside
Documents
(0)AI Contract Breakdown
Uniform Contract FormatNo contract breakdown available.
Cannot generate Contract Breakdown because no documents were found from this contract's source.
Timeline
Organization & Contact Information
Full Description
The purpose of this funding opportunity is to advance the NIH mission by supporting the continuation of the Consortium to Study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE).
Chronic Kidney Disease of Uncertain Etiology (CKDu) causes kidney failure in rural areas of many Low and Middle Income Countries, resulting in a large death toll among the young working age population. Environmental factors are suspected to be causative, but family and geographic clustering add consideration of unrecognized genetic susceptibility. The risk factors identified in other countries are encountered by U.S. patients, so this research will offer valuable insights into the development and progression of tubulointerstitial renal diseases, with broad implications for understanding kidney health and disease in the U.S.
NIDDK, NIEHS, and FIC have jointly funded a consortium that includes Field Epidemiology Sites, a Renal and Environmental Science Core, and a Data Coordinating Center to find causes and potential interventions for CKDu since 2021. This NOFO requests renewal applications for the Field Epidemiology Sites that will continue to identify, recruit, and retain participants in CKDu endemic areas, conduct study visits, and collect biological and environmental samples. Consortium members will continue to collaborate to maximize scientific opportunities and enable discovery science to understand the etiologies of CKDu, the exposures that initiate and affect progression of tubulointerstitial kidney disease, potential therapeutic targets, and future opportunities for public health interventions. The CURE Consortium will serve as a resource for ancillary studies.
This is a forecast for a limited competition Notice of Funding Opportunity (NOFO) that will invite application(s) from eligible organizations to apply. Application(s) will be peer-reviewed and only funded if meritorious.