Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study-Research Project Sites (U01 Clinical Trial Not Allowed)
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The National Institute on Drug Abuse, in collaboration with other NIH Institutes and Centers, is issuing a limited competition notice of funding opportunity under solicitation RFA-DA-27-002 for the Adolescent Brain Cognitive Development Extended (ABCD-E) Study. This initiative seeks to renew research project sites to continue tracking a cohort of nearly 12,000 participants into emerging adulthood. The study focuses on how biological changes and young adult experiences, including physical activity, healthy lifestyles, and technological habits, influence brain development and various social, behavioral, academic, and health outcomes. This opportunity is structured as a U01 cooperative agreement and is limited to current award recipients. Applications are due by July 9, 2026, and will undergo a standard NIH peer-review process to determine funding based on merit. The project utilizes advanced technology, such as wearable sensors and brain scans, to monitor the manifestation of substance use disorders, mental health disorders, and chronic diseases as the participants transition from adolescence into adulthood.
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The National Institute on Drug Abuse (NIDA), with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the research sites for the Adolescent Brain Cognitive Development (ABCD) Study. The ABCD study is the largest long-term study of brain development and child and adolescent health in the United States. This renewal will continue to follow the ABCD cohort into adulthood, when many of the outcomes of interest (e.g., substance use disorders, mental health disorders, chronic diseases, and other health conditions) will manifest. The ABCD Study has been highly successful in recruiting a cohort of almost 12,000 participants beginning at ages 9-10 and assessing them to ages 19-20. This proposed renewal would follow these children for five years through their emerging adulthood. By using cutting-edge technology such as brain scans and wearable sensors, scientists have an unprecedented opportunity to determine how young adult experiences (such as physical activity, healthy lifestyles, new technological habits like videogames or social media, and other Making America Health Again priority areas) interact with each other and with a young adult’s changing biology to affect brain development and social, behavioral, academic, health, and other outcomes. Applications are not being solicited at this time. This is a Forecast for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.
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