Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) 

The National Institutes of Health, through the National Institute of Environmental Health Sciences, has issued solicitation RFA-ES-27-004 for the Superfund Hazardous Substance Research and Training Program. This limited competition P42 grant, which allows for optional clinical trials, is specifically restricted to accredited institutions of higher education as defined by the Higher Education Act. While only these institutions may apply as primary recipients, they are encouraged to subcontract with a variety of domestic or foreign entities, including hospitals, laboratories, state and local governments, and private organizations involved in the management and treatment of hazardous substances. The program focuses on the research and training associated with hazardous substances, with the current notice serving as a reissue of RFA-ES-23-001. The solicitation outlines specific application instructions and review cycles for multi-project center grants for the 2026 through 2028 period. Administrative inquiries and coordination are managed by the National Institute of Environmental Health Sciences under the Department of Health and Human Services.