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Mechanisms Underlying Olfactory Dysfunction in Aging and Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias

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Contract Overview

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The National Institute on Aging (NIA), in collaboration with the National Institute on Deafness and Other Communication Disorders (NIDCD), plans to issue a funding opportunity aimed at research investigating the biological mechanisms linking olfactory decline with aging and Alzheimer's disease (AD) or related dementias. The goal is to better understand how changes in the sense of smell may serve as an indicator of health outcomes in older adults and as a predictor for AD and related dementias. The research scope is broad, encompassing studies involving older adults and animal models, and utilizing diverse scientific approaches such as cellular, molecular, imaging, physiological, omics, and novel methodologies to address existing knowledge gaps. Uncovering olfactory circuit alterations may also lead to the identification of new therapeutic targets to modify disease progression. Although applications are not currently being accepted, this announcement serves as an advance notice to allow researchers time to form collaborative partnerships and prepare responsive proposals. The upcoming solicitation will likely utilize the R01 grant mechanism, encouraging investigators with expertise in aging and olfactory research to consider applying. The funding initiative is managed by the National Institutes of Health under the Department of Health and Human Services, with Coryse St. Hillaire-Clarke, Ph.D., listed as the point of contact for additional information.

General Info

NIA and NIDCD to fund research on olfactory decline linked to aging and Alzheimer's disease.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

Posted

forecast

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
Coryse St. Hillaire-Clarke Ph.D
contact@example.gov
+1 (555) 000-0000

Full Description

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The National Institute on Aging (NIA), with the National Institute on Deafness and Other Communication Disorders (NIDCD), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications that investigate the mechanisms underlying the association between olfactory decline and aging or Alzheimer's disease (AD) and AD-related dementias (ADRD). Understanding these mechanisms may help inform the potential use of olfactory dysfunction with age as an indicator of various health outcomes in older adults (e.g. physical function) and as a predictor of AD/ADRD risk. Identifying circuit-level olfactory changes may also uncover novel targets for developing disease-modifying therapeutic strategies. Studies may include older adults and/or animal models and may employ a variety of approaches, including cellular, molecular, imaging, physiological, omics and new approach methodologies (NAMs) to address the research gaps.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO intends to utilize the R01 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.

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