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Mechanistic Exploration of Therapeutic Targets and Treatable Traits to Improve CNS Outcomes in People with HIV

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Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institute of Mental Health, under the Department of Health and Human Services, plans to issue a Notice of Funding Opportunity using the R01 activity code to support research focused on alleviating central nervous system complications in individuals with HIV. This initiative aims to identify and validate modifiable therapeutic targets and mechanisms by leveraging patient-derived data, systems biology, and innovative pre-clinical or clinical model platforms. The primary objective is to develop effective, mechanism-based interventions that address the complex and heterogeneous nature of CNS dysfunction. This forecast is intended to provide potential applicants time to establish collaborations and develop responsive projects before formal applications are solicited. The agency is seeking investigators with specialized expertise in translational neurobiology, clinical trial methodologies, pre-clinical models, and systems biology. Interested parties can direct inquiries to Vasudev R Rao at the National Institute of Mental Health.

General Info

NIMH seeks research on CNS complications in HIV, targeting therapeutic mechanisms using patient data.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
Vasudev R Rao MS. National Institute of Mental Health (NIMH
contact@example.gov
+1 (555) 000-0000

Full Description

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The National Institute of Mental Health intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research to identify modifiable targets and mechanisms to alleviate clinically relevant central nervous system (CNS) complications in people with HIV. This NOFO supports research that leverages patient derived data and innovative model platforms to identify and validate novel therapeutic targets underlying CNS complications. Building on advances in systems biology, this initiative seeks to identify modifiable mechanisms contributing to CNS dysfunction through clinical studies or pre-clinical model systems. The ultimate goal is to accelerate the development of effective, mechanism-based interventions that address the multifactorial and heterogeneous nature of CNS complications. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise in systems biology, pre-clinical models, clinical trial methodologies and translational neurobiology should consider applying to this NOFO. 

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