National Biomedical Research Centers (P50 Clinical Trial Optional)

The National Biomedical Research Centers (NBRCs) initiative seeks to advance biomedical research by providing specialized scientific expertise, state-of-the-art equipment, infrastructure, and diverse research models accessible to scientists nationwide. Supported broadly by the NIH and other federal agencies, including those with national security interests, the program emphasizes innovative development of human-based models and technologies aimed at minimizing the use of live animal models. Applicants are required to present concrete strategies for reducing, refining, and replacing animal use through complementary alternative methods, particularly focusing on human-relevant approaches. The NBRCs serve dual roles as innovation hubs in fundamental science and translational centers that develop and test novel therapeutic interventions intended for human application. This funding opportunity promotes the leadership of NBRCs in advancing New Approach Methodologies (NAMs), which include sophisticated in vitro and computational models. Clinical trials under this program are permitted only when they involve human-based NAMs. The open competition aims to foster innovation, particularly in NAMs research, leveraging existing nonhuman primate colonies and enhancing capabilities in both basic and translational biomedical research. The National Institutes of Health oversees this effort through the Department of Health and Human Services, with an emphasis on expanding available tools and models that reduce dependence on animal research while accelerating the development of human-relevant treatments.