Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances
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The National Institute on Drug Abuse (NIDA) is seeking to support the expansion of the Collaboratory on Neural Ensembles & Used Substances (NExUS), a project aimed at creating a comprehensive knowledgebase of neural cell populations involved in substance-related experiences and the neurobehavioral states linked to addiction or resilience. The initiative focuses on collecting and sharing detailed datasets that describe neural cells tuned to specific features of substance use, integrating multiple data modalities such as molecular identity, epigenetic state, morphology, and connectivity, and developing scalable tools for analyzing and visualizing cell ensemble composition and structure. Additionally, it aims to advance understanding of the mechanisms by which neural cells or motifs are recruited into coding ensembles. The effort also emphasizes promoting collaboration among funded projects and aligning with other cell atlasing endeavors through coordinated outreach, standardized data practices, common spatial frameworks, and reference taxonomies. This opportunity is forecasted under grant authorities provided in Sections 301 and 405 of the U.S. Code and is managed by the NIH’s National Institute on Drug Abuse within the Department of Health and Human Services. Interested applicants can direct inquiries to the Integrative Neuroscience Branch Program Staff via the provided contact email.
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The National Institute on Drug Abuse (NIDA) seeks to advance its mission by supporting the expansion of the Collaboratory on Neural Ensembles & Used Substances (NExUS), an effort to build a knowledgebase of the neural cell populations and computations altered by substance-associated experiences, and underlying neurobehavioral states characteristic of addiction, or protective against it. This notice is provided to allow prospective applicants to develop applications that achieve the following goals:
1) Collect and share granular datasets descriptive of neural cell populations tuned to tractable features of substance-related experiences
2) Integrate cell-resolved readouts of ensemble activity with other granular data modalities (e.g., molecular cell identity, epigenetic state, morphology, spatial localization or connectivity)
3) Develop tools for analysis and visualization of ensemble composition and geometry, and document their scalability
4) Inform and test models for the mechanisms whereby cells or motifs are recruited into coding ensembles
5) Enable synergies among NExUS-funded projects and with other cell atlasing efforts through coordination of outreach, data standards, analytics, common spatial frameworks, and reference taxonomies
Grant Authorities that allow NIDA to forecast this opportunity are as follows: Section 301 (42 U.S.C. § 241) and Section 405 (42 U.S.C. § 284).
