Pancreatic Cancer Detection Consortium: Management and Data Coordination Unit (U24 Clinical Trial Not Allowed)
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The National Cancer Institute is seeking applications to establish the Management and Data Coordination Unit (MDCU) as part of the Pancreatic Cancer Detection Consortium (PCDC), a key initiative focused on early detection of pancreatic ductal adenocarcinoma (PDAC). The MDCU will serve as a scientific core supporting collaborative efforts through study design, protocol development, statistical analysis, coordination, and data management. Additionally, it will contribute to biorepository development and provide organizational and logistical support to facilitate PCDC activities. This unit plays a crucial role in advancing research priorities identified in the NCI's 2014 Scientific Framework aimed at characterizing precursor lesions and identifying individuals at high risk of progression to pancreatic cancer. The PCDC also includes the Research Units (RUs), which focus on developing and testing new molecular and imaging biomarkers for early detection of PDAC or identifying high-risk patients based on genetic factors, family history, or precursor lesions. The MDCU will coordinate and support these research efforts, ensuring effective data integration and management across the consortium to accelerate translational research and potential early intervention strategies. This initiative is funded by the National Institutes of Health under the Department of Health and Human Services and is not intended to support clinical trials.
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Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) is soliciting applications for the establishment of the Management and Data Coordination Unit (MDCU), one of the two scientific components of the Pancreatic Cancer Detection Consortium (PCDC). The PCDC will continue to address one of the four research priorities identified in the National Cancer Institute's 2014 Scientific Framework for Pancreatic Ductal Adenocarcinoma and conduct research on early detection of pancreatic ductal adenocarcinoma (PDAC) and characterization of its precursor lesions to identify those patients who are at high risk of progression to cancer. The PCDC-MDCU will provide support toward collaborative efforts such as: study design, protocol development, statistical analysis, coordination and data management. Other PCDC-MDCU activities include: coordination and support toward biorepository building; and organizational and logistics support for PCDC activities.
The other scientific component of the PCDC will be the Research Units. The PCDC-RUs will conduct research for the development and testing of new molecular and imaging biomarkers for early detection of PDAC and/or for identifying those patients at high risk of PDAC (because of genetic factors and/or family history or presence of precursor lesions) who could be candidates for early intervention.
