Research Resource for a National Swine Resource and Research Center (U42 Clinical Trial Not Allowed)
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This contract seeks to support the ongoing operations of the National Swine Resource and Research Center (NSRRC), which functions as a centralized national facility dedicated to the creation, breeding, cryopreservation, and distribution of genetically modified swine models for biomedical research. By centralizing these activities, the NSRRC aims to improve reproducibility and reduce variability in research studies, providing investigators with access to high-quality, specific pathogen-free models. The consolidation also helps reduce costs and redundancy for individual laboratories, enabling researchers to concentrate on scientific inquiry rather than managing infrastructure. In addition to maintaining and supplying these genetically modified models, the NSRRC offers essential services such as genotyping, phenotyping, infectious disease monitoring, and distribution of research protocols to facilitate model use. The Center also serves as an educational hub, providing information and training on the appropriate care and utilization of swine models to ensure their relevance to human health and disease studies. Moreover, the NSRRC is positioned to lead efforts in developing alternative or complementary research methodologies, including new approach methodologies (NAMs), alongside traditional in vivo models, thereby advancing the biomedical research community’s capacity for innovation.
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This Notice of Funding Opportunity (NOFO) encourages applications to provide continuing support for a National Swine Resource and Research Center (NSRRC). The NSRRC aims to enable gold-standard science in biomedical research by serving as a centralized national resource for the creation, breeding, cryopreservation, and distribution of genetically modified models. By consolidating these essential functions, the NSRRC significantly reduces variability and improves reproducibility across studies, ensuring that researchers have access to consistent, high-quality, specific pathogen-free models. Centralizing the resource also eliminates redundancy and high costs associated with individual laboratories maintaining separate facilities and breeding programs for these models, allowing investigators to focus their efforts on research rather than infrastructure. Additionally, the NSRRC provides genotyping and phenotyping services, infectious disease monitoring, and protocol distribution to facilitate their use for biomedical research. The Center also serves as a source of information and training related to the care and use of these models in biomedical research to study human health and disease and suitability of a model’s faithful representation of the biological system(s) proposed to be studied. The Center serves as a resource to lead the development of alternative or complementary approaches available, including new approach methodologies (NAMs), alongside in vivo models.