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Selective Precision Targeting (SPoT)

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Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Center for Advancing Translational Science (NCATS), under the National Institutes of Health, is launching the Selective Precision Targeting (SPoT) initiative to develop mechanisms for precise therapeutic drug delivery to hard-to-reach areas of the human body. Utilizing microphysiological systems, the project focuses on delivering medications to challenging locations such as the blood-brain barrier, central nervous system, placenta, retina, or tumors through the use of engineered nanoparticles, extracellular vesicles, or focused ultrasound. The primary objectives of this initiative include optimizing the targeting of nanoparticle therapeutics, assessing biodistribution and off-target effects via multi-organ systems, providing evidence of functional cargo activity, and determining the most effective routes of administration. This opportunity is forecasted under the authority of the Cures Acceleration Network and is categorized under NAICS code 541715.

General Info

NCATS SPoT program develops precise drug delivery methods targeting hard-to-reach body areas using MPS.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

No documents available

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
Passley Hargrove-Grimes Ph.D. National Center for Advancing Translational Sciences (NCATS
contact@example.gov
+1 (555) 000-0000

Full Description

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The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by establishing a new initiative called Selective Precision Targeting (SPoT) to determine a mechanism for precise and on-target therapeutic drug delivery to specific hard-to-reach locations within the human body using microphysiological systems (MPS). Targeted drug-delivery systems, including engineered nanoparticles, extracellular vesicles or focused ultrasound, are methods for delivering medications to a specific area of the body (organ, tissue, or cell) to increase the concentration of the drug in that area. Hard-to-reach locations in the body include the blood–brain barrier, central nervous system, placenta, retina, or a tumor.


More specifically, the initiative goals are to:

  • Optimize specific targeting of nanoparticle therapeutics to the target organ/cell of interest
  • Assess biodistribution and off-target effects using a multi-organ microphysiological system
  • Provide evidence of functional cargo activity
  • Determine optimal route of administration


Grant authorities that allow the National Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network.

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