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Selective Precision Targeting (SPoT)

Active
Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

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The National Center for Advancing Translational Science (NCATS) is initiating a program called Selective Precision Targeting (SPoT) aimed at developing precise mechanisms for therapeutic drug delivery to difficult-to-access areas within the human body. This initiative focuses on utilizing microphysiological systems (MPS) to enhance targeted drug delivery methods such as engineered nanoparticles, extracellular vesicles, and focused ultrasound, with an emphasis on reaching locations like the blood–brain barrier, central nervous system, placenta, retina, or tumors. The program intends to optimize targeting accuracy, evaluate drug distribution and off-target effects using multi-organ MPS models, demonstrate the functional activity of delivered therapeutic cargo, and identify the best routes of administration. This opportunity, governed under the authority of the Cures Acceleration Network, seeks to advance innovative strategies to increase drug concentration at the disease site while minimizing systemic exposure. The project is under the auspices of the Department of Health and Human Services, specifically through the National Institutes of Health, with a point of contact at NCATS available for further information. The SPoT initiative represents a significant step toward improving precision medicine by enabling the delivery of therapeutics to challenging anatomical targets using sophisticated model systems.

General Info

NCATS SPoT program develops precise drug delivery methods targeting hard-to-reach body areas using MPS.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

Posted

forecast

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
Passley Hargrove-Grimes Ph.D. National Center for Advancing Translational Sciences (NCATS
contact@example.gov
+1 (555) 000-0000

Full Description

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The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by establishing a new initiative called Selective Precision Targeting (SPoT) to determine a mechanism for precise and on-target therapeutic drug delivery to specific hard-to-reach locations within the human body using microphysiological systems (MPS). Targeted drug-delivery systems, including engineered nanoparticles, extracellular vesicles or focused ultrasound, are methods for delivering medications to a specific area of the body (organ, tissue, or cell) to increase the concentration of the drug in that area. Hard-to-reach locations in the body include the blood–brain barrier, central nervous system, placenta, retina, or a tumor.


More specifically, the initiative goals are to:

  • Optimize specific targeting of nanoparticle therapeutics to the target organ/cell of interest
  • Assess biodistribution and off-target effects using a multi-organ microphysiological system
  • Provide evidence of functional cargo activity
  • Determine optimal route of administration


Grant authorities that allow the National Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network.

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