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The NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS)

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The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity under the U24 activity code to establish a secure, scalable, and interoperable cloud-based data storage and computing platform. This platform will support the NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS), serving as the primary repository for archiving and distributing human genetic data related to Alzheimer’s disease and related dementias. The initiative focuses on democratizing access to large-scale genomic data through efficient ingestion, curation, and the provision of AI-ready resources and secure workspaces for the research community. Key objectives include ensuring compliance with federal security policies, promoting interoperability with other NIH repositories, and providing comprehensive user training and support. By enhancing data accessibility and reproducibility, the project aligns with the NIH plan for Gold Standard Science and NIA Strategic Directions to maximize the scientific impact of AD/ADRD research. While applications are not currently being solicited, this forecast provides potential applicants time to develop collaborations for the upcoming opportunity.

General Info

NIA seeks to fund a secure, scalable cloud platform for Alzheimer's genetic data management and analysis.

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Office AddressUSA
Contacts
NIA Scientific Contact

Full Description

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The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to develop, operate, and sustain a cloud-based data storage and computing platform that democratizes access to large-scale Alzheimer’s disease (AD) and AD-related dementias (ADRD) genetic and genomic data. The platform must be secure, scalable, and interoperable. The platform will support the NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS), the primary NIA-supported repository for the archiving and distribution of human genetic data related to AD/ADRD. The purpose of the platform will be to:

  • Enable efficient ingestion, curation, harmonization, and analysis of multi-ancestry, large population-scale datasets;
  • Provide robust analysis, visualization, and artificial intelligence -ready resources within secure cloud workspaces;
  • Ensure compliance with federal security and data-sharing policies;
  • Promote interoperability with other NIH- and NIA-supported repositories; and
  • Provide user support, training, and community engagement.

The NOFO aims to foster collaboration, accelerate discovery, and maximize the scientific value and impact of AD/ADRD genetics research for the broader research community.

By improving data accessibility, interoperability, reporting, reproducibility, and scalable computational systems that enable rigorous, reproducible, and transparent research, the NOFO seeks to align with the NIH’s plan for Gold Standard Science and the AD/ADRD Research Implementation Milestones. Additionally, the NOFO seeks to address the Academies of Sciences, Engineering, and Medicine's recommendation of ensuring broad, secure access to high-value datasets and enhancing data usability to maximize the return on research investments and support future discoveries in AD/ADRD. Moreover, the NOFO intends to directly advance NIA’s Strategic Directions, particularly Goal G to support the infrastructure and resources necessary for high-quality research, by strengthening data sharing, computational infrastructure, and research rigor across the AD/ADRD community.

The NOFO intends to utilize the U24 activity code.

Applications are not being solicited at this time. This notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

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