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Transformative Non-Invasive/Minimally Invasive Technologies for Imaging the Olfactory System Across Scales (R01 Clinical Trial Optional)

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The National Institute on Deafness and Other Communication Disorders, in collaboration with the National Institute of Biomedical Imaging and Bioengineering, is issuing a Notice of Funding Opportunity under solicitation RFA-DC-27-003. This R01 activity code initiative seeks to develop or adapt transformative non-invasive and minimally invasive imaging technologies to visualize the human peripheral and central olfactory systems, including the olfactory bulb and epithelium, at previously unattainable spatial and temporal resolutions. The goal is to overcome current challenges related to restricted accessibility and low signal resolution to better understand biological mechanisms and improve the diagnostic accuracy of olfactory disorders. The program encourages multimodal approaches and collaborative investigations involving expertise in olfaction, biomedical imaging, biochemistry, bioengineering, and biophysics. Potential technologies of interest include cell specific biomarkers, fluorescence imaging, specialized endoscopes, and optical, acoustic, molecular, hemodynamic, and diffusion imaging. Managed by the National Institutes of Health within the Department of Health and Human Services, the solicitation allows for optional clinical trials and requires applications to be submitted through approved systems such as ASSIST, S2S, or Grants.gov Workspace in accordance with NIH application guidelines.

General Info

NIH funding for developing non-invasive imaging technologies to visualize human olfactory systems.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
Merav Sabri Ph.D. National Institute on Deafness and Other Communication Disorders
contact@example.gov
+1 (555) 000-0000

Full Description

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The National Institute on Deafness and Other Communication Disorders (NIDCD), with the National Institute of Biomedical Imaging and Bioengineering (NIBIB), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on in vivo high-resolution imaging of the human olfactory system. Currently, there are limited non-invasive technologies available for imaging the living human peripheral and central olfactory system with high spatial and temporal resolution. Imaging the olfactory system in the laboratory and in the clinic is essential to understanding underlying biological mechanisms as well as the etiology of an olfactory disorder. Such imaging has proven challenging due to the olfactory system’s unique anatomical and functional characteristics such as restricted accessibility, multiple cell types, and low signal resolution. Addressing these challenges will require multimodal approaches including leveraging existing advanced tools and technologies and developing new tools tailored for the olfactory system. Recent advances in minimally invasive and non-invasive imaging technologies, such as cell specific biomarkers, fluorescence imaging, specialized endoscopes, optical and acoustic imaging, molecular imaging, and hemodynamic and diffusion imaging have the potential to transform our ability to image and investigate the peripheral and central olfactory system in the living human with superior temporal and spatial resolution and eventually improve diagnostic accuracy of olfactory disorders. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Applications must leverage advanced non-invasive/minimally invasive imaging technologies to visualize peripheral (e.g., olfactory- and non-olfactory epithelium) and central olfactory (e.g., olfactory bulb) targets at a resolution previously unattainable. In addition, collaborative investigations combining expertise in olfaction, biomedical imaging, biochemistry, bioengineering, biophysics, etc. will be encouraged and investigators should also begin considering applying for this application.

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