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Transformative Non-Invasive/Minimally Invasive Technologies for Imaging the Olfactory System Across Scales (R01 Clinical Trial Optional)

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Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institute on Deafness and Other Communication Disorders (NIDCD), in collaboration with the National Institute of Biomedical Imaging and Bioengineering (NIBIB), plans to issue a funding opportunity for research focused on developing advanced non-invasive and minimally invasive imaging technologies aimed at the human olfactory system. This initiative addresses the current limitations in imaging the living peripheral and central olfactory structures with high spatial and temporal resolution, which is critical for understanding the biological mechanisms and causes of olfactory disorders. The complexity of the olfactory system, characterized by limited accessibility, diverse cell types, and low signal resolution, demands innovative multimodal approaches that integrate existing advanced technologies and new tool development. The research encouraged under this funding opportunity will explore modalities such as cell-specific biomarkers, fluorescence imaging, specialized endoscopes, optical and acoustic imaging, molecular imaging, as well as hemodynamic and diffusion imaging to achieve unprecedented visualization of olfactory tissues including the olfactory epithelium and olfactory bulb. Collaborative proposals crossing multiple disciplines like olfaction, biomedical imaging, biochemistry, bioengineering, and biophysics are highly encouraged. Although applications are not being accepted at this time, this advance notice aims to give prospective applicants ample time to form collaborations and develop competitive projects. The funding announcement will utilize the R01 grant mechanism and will support research that can significantly improve diagnostic techniques for olfactory disorders through transformative imaging advancements.

General Info

NIDCD and NIBIB seek R01 proposals for advanced non-invasive olfactory imaging technologies development.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

Posted

forecast

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
Merav Sabri Ph.D. National Institute on Deafness and Other Communication Disorders
contact@example.gov
+1 (555) 000-0000

Full Description

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The National Institute on Deafness and Other Communication Disorders (NIDCD), with the National Institute of Biomedical Imaging and Bioengineering (NIBIB), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on in vivo high-resolution imaging of the human olfactory system. Currently, there are limited non-invasive technologies available for imaging the living human peripheral and central olfactory system with high spatial and temporal resolution. Imaging the olfactory system in the laboratory and in the clinic is essential to understanding underlying biological mechanisms as well as the etiology of an olfactory disorder. Such imaging has proven challenging due to the olfactory system’s unique anatomical and functional characteristics such as restricted accessibility, multiple cell types, and low signal resolution. Addressing these challenges will require multimodal approaches including leveraging existing advanced tools and technologies and developing new tools tailored for the olfactory system. Recent advances in minimally invasive and non-invasive imaging technologies, such as cell specific biomarkers, fluorescence imaging, specialized endoscopes, optical and acoustic imaging, molecular imaging, and hemodynamic and diffusion imaging have the potential to transform our ability to image and investigate the peripheral and central olfactory system in the living human with superior temporal and spatial resolution and eventually improve diagnostic accuracy of olfactory disorders. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Applications must leverage advanced non-invasive/minimally invasive imaging technologies to visualize peripheral (e.g., olfactory- and non-olfactory epithelium) and central olfactory (e.g., olfactory bulb) targets at a resolution previously unattainable. In addition, collaborative investigations combining expertise in olfaction, biomedical imaging, biochemistry, bioengineering, biophysics, etc. will be encouraged and investigators should also begin considering applying for this application.

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