This Government Contract opportunity from Department Of Health And Human Services was posted on May 20, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Digital Twin Modeling for Complex Diseases

Closed

Federal

Submission Closed06/07/2026, 04:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541715

New

Federal

Advanced Capability Research & Development

Missile Defense Agency (mda)

POSTED

DEADLINE

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Solicitation # W912GY-25-S-C001

The U.S. Army Contracting Command – Sierra Army Depot (ACC-SIAD) has issued Commercial Solutions Opening (CSO) solicitation W912GY-25-S-C001 to modernize its Organic Industrial Base (OIB). This initiative focuses on enhancing the speed of battle and force projection through the procurement of innovative commercial items, technologies, and services. Key priority areas include advanced manufacturing, connected digital enterprises, automation and robotics, digital twins, cybersecurity, and agile or flexible facilities. The program is structured around several continuously open Areas of Interest (AoI), which include logistics and inventory management modernization, airfield maintenance, energy and environmental management, and public-private partnerships. Authorized under DFARS Subpart 212.70 and 10 U.S.C. § 3458, this streamlined acquisition process is open to both traditional and non-traditional defense contractors. The solicitation remains open until June 30, 2030, utilizing a multi-phased evaluation process consisting of solution briefs, presentations or pitches, and commercial solution proposals. Awards are intended to be fixed-price contracts issued under FAR Part 12 Commercial Item Procedures. Eligible respondents must be registered in the System for Award Management (SAM) and the PIEE invoicing system. Specific requirements for individual needs, such as the procurement of a Roll Off Truck under AoI W912GY-26-S-C0001, are managed through separate technical specifications and submission deadlines.

W6QK Siad Contr Office

POSTED

DEADLINE

Synthetic Training Environment (STE) Virtual Software (VSW)

Solicitation # STE-VSW-26-0006

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POSTED

DEADLINE

Missile Defense Agency - Advanced Capability Concepts

Solicitation # HQ0860-25-S-C001

The Missile Defense Agency (MDA) has issued solicitation HQ0860-25-S-C001 for its Advanced Capability Concepts program, an ongoing opportunity open from May 9, 2025, to May 8, 2030. The agency seeks innovative concepts, scientific breakthroughs, and prototype demonstrations to enhance the robustness and effectiveness of all Missile Defense System elements. Key focus areas include kinetic and hypersonic defense, command and control battle management, integrated non-kinetic and electronic warfare, and disruptive technologies such as AI/ML, resilient networking, and advanced sensors. This is a two-step process where industry is invited to submit white papers on a rolling basis, which are then evaluated for potential negotiation and award. Submissions must follow strict formatting guidelines, including a 10-page limit for the combined executive summary and program description, and must include a Rough Order of Magnitude cost estimate and a program summary quad chart. Awards may be structured as either FAR-based procurement contracts or Other Transaction (OT) agreements, depending on the offeror's recommendation and eligibility. Evaluation is based on a trade-off process prioritizing technical achievement, research capabilities, and program management. Offerors must maintain active SAM.gov registration, disclose any organizational conflicts of interest, and comply with NIST SP 800-171 for safeguarding controlled unclassified information. Performance is centered in Huntsville, Alabama, though the agency emphasizes rapid development and compressed timelines for the transition of breakthroughs into acquisition programs.

Missile Defense Agency (mda)

POSTED

DEADLINE

R3PEATS Multi-Team Triangulation: Collaborative Cross-Method Approaches to Scientific Discovery (RM1)The R3PEATS Multi-Team Triangulation initiative, managed by the National Institutes of Health under the Department of Health and Human Services, focuses on collaborative cross-method approaches to scientific discovery. This program supports coordinated teams investigating central biomedical research questions using complementary populations, model systems, or methods. A primary objective is to enhance scientific excellence by identifying signal robustness and biological variability while integrating replication directly into the research design. This effort is part of the broader NIH Common Fund program dedicated to Rigor, Replicability, and Reproducibility to Promote Excellence, Accuracy, and Translation in Science. The opportunity is currently listed as a forecast with a posted date of September 11, 2026, and interested parties can contact the R3PEATS Program for further information.

National Institutes Of Health

POSTED

DEADLINE

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National Institutes Of Health

POSTED

DEADLINE

R3PEATS Grassroots Rigor Projects: Individual Metascience and Individual Laboratory Capacity-Building (RP1)The National Institutes of Health, under the Department of Health and Human Services, is issuing a forecast for R3PEATS Grassroots Rigor Projects focusing on Individual Metascience and Individual Laboratory Capacity-Building. This initiative is part of the NIH Common Fund's broader program to promote excellence, accuracy, and translation in science by enhancing rigor, replicability, and reproducibility. The program supports two distinct project types designed to improve research practices. Metascience projects focus on the development and evaluation of infrastructure, metrics, guidelines, and tools to ensure high-quality research. Laboratory Capacity-Building projects assist labs in implementing new processes and techniques related to replicability while documenting the factors that impact research outcomes.

National Institutes Of Health

POSTED

DEADLINE

Climate Program Office (CPO) FY2026 Earth System Science and Services Partnership

Solicitation # NOAA-OAR-CPO-2026-33326

The Climate Program Office FY2026 Earth System Science and Services Partnership is a federal solicitation by the Department of Commerce NOAA to support research and activities aligned with understanding and predicting changes in the Earth's atmosphere, oceans, coasts, land, and ice. The program focuses on collaborative efforts involving numerical modeling, observations, monitoring, data impact evaluations, and stakeholder engagement to assess effects on ecosystems, weather, hazards, and infrastructure. Total available funding for this initiative is anticipated to be approximately 10 million dollars. Eligible applicants are limited to non-profit research institutions or academic institutions of higher learning that offer doctoral degrees in NOAA-related sciences, though multi-institution applications are not permitted. Interested parties must submit their responses by October 26, 2026.

Department Of Commerce Noaa

POSTED

DEADLINE

Specialized HPC Support (AI/ML & Quantum)

W2R2 USA Engr R & D Ctr

POSTED

DEADLINE

Physiological and Cognitive Testing Services

NASA Shared Services Center

POSTED

DEADLINE

RNA-Seq Bioinformatics Analysis

Office Of Acquisiton Grants

POSTED

DEADLINE

Industrial Security Technologies, Strategy, and Research (ISTS/ISSR)

Defense Ci And Security Agency

POSTED

1 day ago

DEADLINE

in 10 days

AI Contract Overview

This contract focuses on the development of computational models, known as digital twins, to simulate the progression of complex diseases. These models will integrate multi-omics data, clinical information, and environmental factors to provide a comprehensive representation of disease dynamics. The purpose is to use these digital twins to evaluate potential therapeutic interventions in a simulated environment, enhancing understanding and treatment strategies for various health conditions. Issued by the Advanced Research Projects Agency for Health (ARPA-H) under the Department of Health and Human Services, this subcontract targets organizations capable of advanced modeling and bioinformatics work under the NAICS code 541715. The solicitation was posted on May 20, 2026, with responses due by June 7, 2026. Although specific location details are not provided, the contract is intended to support innovative health research initiatives through sophisticated computational tools that integrate diverse biomedical data sources.

General Info

Develop digital twin models simulating disease progression using multi-omics and clinical data.

Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-h)View Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

DC, USA

Set-Aside

NONE

Documents

This scope was carved out of ARPA-H-SN-26-155.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

Intelligent Generator of Research (IGoR)

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No contract breakdown available.

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Timeline

PhaseClosed

PostedMay 20

subcontract

Response DeadlineJun 7

Deadline has passed

Submission Closed

06/07/2026, 04:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-h)

ContactsNo contacts available

OfficeN/A

Organization / Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-h)

View Agency Profile

Office AddressN/A

ContactsNo contact information available

Full Description

Create computational models ('digital twins') of disease progression using multi-omics, clinical, and environmental data to simulate therapeutic interventions.