Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)

The Gabriella Miller Kids First Pediatric Research Program, under solicitation PAR-27-071, is a National Institutes of Health initiative inviting applications to submit pediatric cohorts for whole genome sequencing and related omics assays. The program focuses on elucidating the genetic contributions to childhood cancers and congenital anomalies, investigating their genetic etiology, and studying the molecular associations between these conditions and increased cancer risk. Accepted assays include whole genome, exome, and transcriptome sequencing, as well as long-read sequencing, proteomics, and epigenomic assays of tumor or affected tissue. All resulting sequencing, clinical, and phenotypic data will be integrated into the Kids First Data Resource Center for community sharing. Applicants must be registered in SAM.gov, eRA Commons, and Grants.gov, with a submission deadline of January 11, 2027. Selected investigators are required to ship samples to designated data generating centers within six months of award notification, with an earliest start date of April 2027. Evaluation is based on scientific and technical merit, specifically focusing on the significance of the trait to human health, the evidence for a genetic component, and the potential to strengthen the Kids First Data Resource. Programmatic priority is given to cohorts representing conditions not previously sequenced. While this is a resource access program where applicants enter $0 for federal funds requested, recipients must adhere to strict cybersecurity plans modeled after the NIST framework and comply with all human subjects and biosafety regulations. Clinical trials are not allowed under this solicitation.