Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)

The Gabriella Miller Kids First Pediatric Research Program, led by the NIH, seeks applications for submitting pediatric cohort samples to designated sequencing centers supported by the program. The focus is on whole genome sequencing to investigate the genetic basis of childhood cancers and congenital anomalies. Applicants are encouraged to submit proposals involving existing cohorts of pediatric cancer or congenital anomalies to better understand the somatic and germline genetic contributions to these conditions, explore the molecular links between congenital anomalies and increased cancer risk, or broaden the variety of pediatric disorders included in the Kids First Data Resource. The program accepts applications for a range of genomic and molecular analyses, including whole genome, exome, and transcriptome sequencing, as well as advanced methods like long-read sequencing, proteomics, and epigenomic assays when justified. All generated data, along with clinical and phenotypic information, will be integrated into the Kids First Data Resource Center and shared with the research community to facilitate further discoveries in pediatric disease genetics. The initiative is coordinated under the Department of Health and Human Services through the National Institutes of Health, with contact available via the Kids First Program email.