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Extracellular Vesicle Therapeutics for Regenerative Medicine (ExTReMe)

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Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Center for Advancing Translational Science (NCATS), under the National Institutes of Health, is forecasting the Extracellular Vesicle Therapeutics for Regenerative Medicine (ExTReMe) program. This initiative aims to advance research and the translation of extracellular vesicles, such as exosomes and microvesicles, as cell-free therapeutic tools for tissue repair and regeneration. The program focuses on utilizing the natural intercellular communication capabilities of EVs to deliver therapeutic agents or modulate signaling pathways. Key areas of interest include the development of direct EV therapies produced under GLP conditions for off-the-shelf use, as well as the creation of designer EVs personalized to individual patient needs. This opportunity is authorized under the Cures Acceleration Network and is managed by the Department of Health and Human Services.

General Info

NCATS funds ExTReMe program to develop engineered extracellular vesicle therapies for regenerative medicine.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

No documents available

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
Christine Happel Ph.D. National Center for Advancing Translational Sciences (NCATS
contact@example.gov
+1 (555) 000-0000

Full Description

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The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by advancing research on extracellular vesicles (EVs) and their use as therapeutics in the field of regenerative medicine.


The main objective of this program, Extracellular Vesicle Therapeutics for Regenerative Medicine (ExTReMe), is to support the translation of EV-based therapeutics in regenerative medicine. EVs, like exosomes and microvesicles, are crucial mediators of intercellular communication, carrying diverse cargo like proteins, nucleic acids, and lipids. In regenerative medicine, EVs play a significant role by influencing cellular behaviors during tissue repair and regeneration. Due to their natural function in intercellular communication, EVs represent a novel, cell-free, therapeutic tool. EVs can be further engineered to deliver therapeutic agents or modulate signaling pathways involved in repair/regeneration.


Areas of interest for ExTReMe could include, but are not limited to:

  1. direct EV therapy (stem cell-isolated EVs produced under GLP conditions, and stored as off-the-shelf therapies);
  2. designer EVs (personalized to the individual patient’s needs).


Grant authorities that allow the National Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network

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