Health and Extreme Weather Solutions-Focused Research Hubs (U54 - Clinical Trial Optional)
Contract Overview
Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.
AI Contract Overview
The National Institute of Environmental Health Sciences plans to release a funding opportunity for research hubs that address the public health impacts of extreme weather and cumulative environmental exposures, such as wildfire smoke, extreme heat, flooding, hurricanes, and drought. These hubs will be multidisciplinary, led by teams partnering with non-academic entities including public health departments, community organizations, Tribal groups, healthcare systems, and emergency agencies, with strong emphasis on meaningful, equitable community engagement. The program supports translational research across the spectrum from basic to implementation science, prioritizing problem-driven, solutions-oriented approaches that lead to scalable, measurable improvements in population health, particularly for vulnerable populations across all life stages. Applicants are encouraged to form consortia that foster balanced partnerships and integrate community input throughout the research lifecycle. The funding will be awarded through the U54 cooperative agreement mechanism, which enables substantial federal involvement in guiding and coordinating the efforts of funded hubs. Recipients are expected to collaborate closely with the HEW Research Coordination and Data Center and engage in shared initiatives such as data harmonization, metric development, and cross-site dissemination. The hubs will serve as regional resources, supporting infrastructure, pilot projects, and sustained community partnerships. Federal program staff will play an active role in strategic alignment with NIH priorities and facilitating collaboration across awarded sites. This opportunity, forecasted for release in June 2026, falls under statutory authorities for NIH and NIEHS grantmaking and is open to applications from institutions across the United States without set-aside restrictions.
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Full Description
The National Institute of Environmental Health Sciences (NIEHS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications that propose translational research hubs with multiple highly integrated components focused on research, capacity building, and community/public health translation for regionally relevant topics related to the health impacts of extreme weather and cumulative exposures, including but not limited to wildfire smoke, extreme heat, flooding, hurricanes, drought, and other climate-related hazards affecting populations at heightened risk across the lifespan. Responsive applications will be led by a multidisciplinary team of investigators with non-academic partners, such as state and local public health departments, community-based organizations, Tribal entities, health care systems, and emergency preparedness agencies. Consortia of multiple institutions are encouraged, particularly those that demonstrate meaningful community engagement and balanced, mutually beneficial partnership structures. Research can be situated at different nodes on the translational research continuum, spanning from fundamental to implementation research with a focus on being problem-based and solutions oriented, and should clearly inform pathways to support implementation, scalability, and measurable public health impact. Award recipients will be expected to collaborate with the HEW Research Coordination and Data Center(s) and other members of the HEW Community of Practice, including participation in data harmonization efforts, shared metrics development, and cross-site dissemination activities. This NOFO will utilize the U54 activity code, that supports specialized centers that function as regional resources for targeted research initiatives, including support for infrastructure development, pilot projects, and partnerships with affected communities throughout the research lifecycle. The U54 is a cooperative agreement that anticipates substantial federal programmatic staff involvement to assist investigators in the achievement of project objectives, including coordination across funded hubs, strategic alignment with NIH priorities, and facilitation of cross-institute collaboration. Grant authorities that allow NIEHS to forecast this opportunity are as follows: 42 USC 285l (NIEHS specific); 42 USC sections 241 (NIH grant authorities).
