NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System

The NIH Blueprint Initiative aims to support and enhance the development and application of germline and somatic transgenic and gene-editing technologies in experimental models that replicate key aspects of human brain anatomy, circuitry, cognition, behavior, and lifespan. Building upon existing marmoset gene-editing infrastructure, this effort seeks to integrate New Approach Methodologies (NAMs) alongside other models to deepen the understanding of human brain function and neurological diseases. A particular focus is placed on developing and validating human-derived NAMs that allow cross-species developmental comparisons, which are crucial for studying complex neurodevelopmental and behavioral disorders such as autism spectrum disorders and schizophrenia that current models struggle to fully capture. The initiative emphasizes the importance of selecting and justifying appropriate experimental models, especially when addressing neuroanatomical and functional questions related to brain disease and cognition. It aims to accelerate research advances by prioritizing investment in human-derived NAMs for conditions that remain inadequately modeled. The contract is managed under the authority of the Department of Health and Human Services through the National Institutes of Health and specifically targets projects that contribute to tools for germline gene editing within the nervous system. Interested parties can seek further information or contact the program directly via the provided email for collaboration or grant opportunities.