Single Source Competition: Continuation of the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D) - Resource Center (U24 Clinical Trial Not Allowed)

The National Institutes of Health, through the NIDDK and NHLBI, is issuing a single source competition for a cooperative agreement to support the Resource Center for the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D). This initiative aims to advance the understanding of cardiovascular disease in type 1 diabetes by collecting, analyzing, and sharing cardiovascular tissue from organ donors with type 1 diabetes, type 2 diabetes, and those without diabetes. The Resource Center is responsible for expanding the biorepository by collecting approximately 30 cases per year, performing extensive tissue characterization including microCT imaging and RNA quality assessments, and maintaining a data commons in collaboration with the NHLBI BioData Catalyst. Additionally, the center coordinates consortium activities and manages the distribution of biosamples to approved investigators. The funding opportunity, identified as RFA-DK-27-109, allows for a maximum project period of five years with annual direct cost limits of 1.5 million dollars. Applications are evaluated based on scientific and technical merit through the NIH peer review system, focusing on significance, investigator qualifications, and innovation. Eligible organizations must maintain active registrations in the System for Award Management and eRA Commons. The agreement is governed by 42 CFR Part 52 and 2 CFR Part 200, requiring strict adherence to data sharing policies, cybersecurity incident reporting within 48 hours of discovery, and the establishment of inter-member agreements regarding intellectual property and biospecimen sharing.