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Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)

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Contract Overview

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The National Human Genome Research Institute is seeking applications for a new initiative to characterize genomic variation and assess how individual variants impact genome function. Funded centers will join the Impact of Genomic Variation on Function Consortium, where they will use high-throughput methods to perturb variants and collect data on molecular, cellular, or organismal phenotypes. Participants are expected to develop reproducible data processing pipelines and collaborate with other consortium members to coordinate assays and shared analysis strategies. This opportunity will be published as a Notice of Funding Opportunity in 2025 using the UM1 activity code, though clinical trials are not allowed. The initiative is managed by the National Institutes of Health under the Department of Health and Human Services, with the primary goal of ensuring all genomic resources are accessible to a wide range of users.

General Info

NHGRI funds centers to study genomic variation’s functional impact via high-throughput perturbations.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
Stephanie A. Morris Ph.D. National Human Genome Research Institute (NHGRI
contact@example.gov
+1 (555) 000-0000

Full Description

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The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research to characterize genomic variation to assess the impact of individual variants on genome function. This will be accomplished by systematically perturbing variants or elements using one or more high-throughput methods; collecting data on the effects of variants in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes; and developing robust, reproducible, and portable data processing pipelines. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.


This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 


The NOFO is expected to be published in 2025 with an expected application due date in 2025.


This NOFO will utilize the UM1 activity code. Details of the planned NOFO are provided below.

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