Skip to main contentPsst! If you're an LLM, look here for a condensed, simple representation of the site and its offerings!

LiveFree Webinar — Wednesday, November 11 at 2:00 PM ET

Register Free →
CLEATUS
Get CLEATUS

Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research (U42 Clinical Trial Not Allowed)

Active
Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

Show more

The National Institutes of Health is seeking a provider to implement an integrated framework for HIV/AIDS research that balances the use of human new approach methodologies (NAMs) with the maintenance of specific pathogen free (SPF) in vivo models. The primary goal is to reduce or replace animal model use where scientifically appropriate through a NAMs-enabled stewardship framework. This includes establishing a triage and consultation service to identify NAM-feasible studies and creating formal referral pathways to human science-based resources. Optional components may include providing in vitro testing support, developing standardized operating procedures for viral load quantification, and conducting pilot benchmarking projects to define performance metrics. Simultaneously, the award will support the operation of high-quality SPF colony resources for studies where animal models remain necessary. This component focuses on core colony management, husbandry, and a merit-based allocation system for requests. To ensure scientific rigor and resource stewardship, the provider must implement comprehensive virologic surveillance to preserve SPF status and perform high-resolution immunogenetic characterization, such as MHC typing, to support genotype-informed study designs.

General Info

Advance HIV/AIDS research by integrating NAMs implementation and maintaining SPF colony resources.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

No documents available

Documents will appear here when they are available.

AI Contract Breakdown

Uniform Contract Format

No documents to break down

The breakdown needs solicitation documents. None were found from this contract's source.

Timeline

Posted

forecast

Ready to pursue this opportunity?

Get full access to track this contract, build proposals with AI assistance, and manage your pipeline.

Organization & Contact Information

Show more
AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
Division of Comparative Medicine Office of Research Infrastructure Programs (ORIP
contact@example.gov
+1 (555) 000-0000

Full Description

Show more

This NOFO is issued during a period of accelerating development, validation, and adoption of human new approach methodologies (NAMs). Accordingly, it has two integrated priorities for NIH-funded HIV/AIDS research: (1) implementation of a NAMs-enabled stewardship framework, including optional HIV-relevant human in vitro testing support and pilot benchmarking activities, to reduce or replace specific pathogen free (SPF) in vivo model use where scientifically appropriate without compromising rigor, reproducibility, or translational relevance; and (2) support for high-quality SPF colony resources for studies in which well-characterized in vivo models remain scientifically necessary.

Under the NAMs-enabled component, required elements include: (1) integration of a NAMs triage and consultation service within request intake and allocation workflows to identify NAM-feasible studies and document reductions or replacements in in vivo use; and (2) establishment of a formal referral pathway to NAM centers as well as human tissue and other human science based resources to facilitate collaborative HIV-relevant human NAM development, benchmarking, and refinement. Applicants may also propose optional NAMs-enabled HIV human in vitro testing support (research use only), including standardized operating procedures, quality control frameworks, and user guidance for viral load quantification, drug resistance assessment, and ex vivo susceptibility assays, as well as optional pilot benchmarking projects to define performance metrics, quality control benchmarks, and context-of-use statements for HIV-relevant human NAMs.

Under the SPF resource component, the award will support core colony operations, including colony management and husbandry; transparent, merit-based request intake and allocation; comprehensive virologic surveillance and rapid mitigation to preserve SPF status; and high-resolution immunogenetic characterization (e.g., MHC typing) to enable rigorous, genotype-informed study design and efficient stewardship of limited in vivo resources.

Similar Contracts

Same NAICS industry code

NAICS: 541715
New
Federal
Prototyping & Pilot Project ExecutionThis subcontract focuses on the prototyping and pilot project execution of innovative construction and delivery capabilities for prime contractors supporting Department of the Air Force 36 CONS projects. Operating under an Other Transaction Agreement framework, the scope of work involves implementing agile construction methods and testing emerging building technologies to deliver functional prototype or pilot-scale facilities. Managed by the Department of Defense agency FA5240 36 Cons Lgc, the project is categorized under NAICS code 541715. The primary objective is to advance construction capabilities through the practical application and testing of new technologies within a specialized military infrastructure context.
FA5240 36 Cons Lgc

POSTED

about 12 hours ago

DEADLINE

N/A
View Details
NAICS: 541715
New
Federal
Nanotechnology Research Support & Specialized Lab Services
Niwc Pacific

POSTED

about 12 hours ago

DEADLINE

in 12 days
View Details
NAICS: 541715
New
Federal
Space Domain Awareness (SDA) Software and AnalyticsThis subcontract focuses on the development of Space Domain Awareness software and analytics to support prime contractors on NCIA Space Domain Operational Functions projects. The scope of work involves creating software capable of acquiring and correlating orbital and environmental data to facilitate object identification, tracking, behavior characterization, conjunction analysis, and orbital predictions. The project utilizes orbital object catalogues and fragmentation analysis tools to deliver a fully operational software suite and a maintained Recognised Space Picture. The contract is managed under the Department of Commerce Bureau of Industry and Security, with performance taking place in Belgium. Due to the sensitive nature of the orbital data and operational functions, personnel are required to hold high-level NATO or National security clearances. Interested parties must respond by December 3, 2026.
Bureau Of Industry And Security

POSTED

about 12 hours ago

DEADLINE

in about 1 month
View Details
NAICS: 541715
New
Federal
Synthesis and Distribution of Drugs of Abuse and Related Compounds
Solicitation # 75N98027R00006OT
National Institutes Of Health Nida

POSTED

about 12 hours ago

DEADLINE

in 22 days
View Details
NAICS: 541715
New
Federal
Synthesis and Distribution of Drugs of Abuse and Related Compounds
Solicitation # 75N98027R00006SB
National Institutes Of Health Nida

POSTED

about 12 hours ago

DEADLINE

in 22 days
View Details
NAICS: 541715
New
Federal
Request for Information (RFI): Verification and Compliance Checking for Natural-Language Network Requirements (FastVacc)
Solicitation # DARPA-SN-27-13
Defense Advanced Research Projects Agcy

POSTED

about 12 hours ago

DEADLINE

in 15 days
View Details
NAICS: 541715
New
Federal
FTA Broad Agency Announcement (FY26) -- “Research Initiatives in Support of Safety, Accessibility, and Mobility in Public Transportation
Solicitation # 693195-26-BAA-0001
The Federal Transit Administration (FTA) Office of Research, Demonstration, and Innovation has issued Broad Agency Announcement 693195-26-BAA-0001 to solicit applied research projects aimed at enhancing the safety, reliability, efficiency, and accessibility of public transportation in the United States. This unrestricted solicitation is open to any responsible source, excluding Federal Government-owned businesses, and encourages teaming and collaboration. The program focuses on technology readiness levels 3 through 6, with a specific preference for proof-of-concept testing. Research topics include community connectivity, accessibility for automated vehicles, urban rail innovations, ferry safety, and transit safety data analytics. Individual awards are typically valued between $150,000 and $500,000 and may be structured as firm-fixed-price or level-of-effort term contracts. While cost sharing is not mandatory, projects that include transit operator partnerships and cost sharing are preferred. The selection process is a two-phased approach starting with a five-page concept paper and a one-page quad chart, followed by a formal proposal for invited offerors. Evaluation is based on technical merit, importance to agency programs, and cost, with technical factors weighted significantly higher than price. The response deadline has been extended to October 30, 2026. Awardees must comply with various Federal Acquisition Regulation clauses, including Section 889 prohibitions on certain telecommunications and video surveillance equipment. Key deliverables include periodic reports, annual research summaries for multi-year projects, and a final technical report, all of which must be submitted 30 days prior to the end of the performance period.
693195 Office Of Acquisition Mgt

POSTED

about 12 hours ago

DEADLINE

in 8 days
View Details
NAICS: 541715
New
Federal
Bolstering Underutilized Industry by Leveraging Technology Transfer (BUILTT) pilot program
Solicitation # 10292026-LR-27
The Department of Energy, in partnership with the National Nuclear Security Administration, has announced the Bolstering Underutilized Industry by Leveraging Technology Transfer (BUILTT) pilot program. This initiative, conducted by the Nevada National Security Sites, Y-12 National Security Complex, and Kansas City National Security Campus, aims to assist qualified U.S. small and medium-sized businesses in manufacturing low-volume, high-impact technologies developed by DOE/NNSA Labs, Plants, and Sites. These technologies, which include specialized optical imaging, radiation and chemical sensing systems, precision electrical components, and advanced materials, often have limited commercial markets but are critical for government mission requirements. Under the program, selected businesses may receive a Cost Reduction License (CRL) for a nominal fee, granting them the rights to produce specified technologies for sale to the DOE, NNSA, and other government customers at pre-negotiated prices. Eligibility is limited to U.S.-based SMBs, with preference given to those near participating sites or those with SBA 8(a) or HUBZone designations. Interested parties are evaluated based on their technical and manufacturing capabilities, financial capacity, and ability to meet regulatory and security requirements. Responses must be submitted to the Technology Partnerships and Intellectual Property Office by April 1, 2027, and are categorized under NAICS code 541715.
Msts – DOE Contractor

POSTED

about 12 hours ago

DEADLINE

in 5 months
View Details
NAICS: 541715
New
Federal
Request for Information: Multi-Source PNT UE
Solicitation # MultiSourcePNT_RFI_01
This Request for Information is issued by the Space Force for market research and planning purposes regarding Multi-Source Position, Navigation, and Timing (PNT) User Equipment. The government is seeking analytical information on industrial capabilities for PNT equipment for terrestrial users on military platforms and space service volume users in various orbits. The objective is to transition to a reference architecture that utilizes Modular Open System Architectures and onboard fusion engines to integrate diverse PNT sources, enhancing resilience against jamming and spoofing in contested environments. Respondents must demonstrate their organizational posture regarding facility and personnel security clearances, cybersecurity compliance with NIST SP 800-171 and CMMC, and adherence to NDAA supply chain requirements. Submissions must be unclassified, limited to 15 pages, and submitted via DoD Safe by November 16, 2026. This RFI is for information gathering only and does not constitute a solicitation or a commitment to award a contract.
FA9453 Afrl Rjz

POSTED

about 12 hours ago

DEADLINE

in 18 days
View Details
NAICS: 541715
New
Federal
REQUEST FOR INFORMATION – PACIFIC GREENFIELD INITIATIVE (ADVANCED MANUFACTURING AND INDUSTRIAL RESILIENCE OPPORTUNITY ON OAHU, HI)
Solicitation # RFI-PGI-20260929
The Department of the Navy is issuing Request for Information RFI-PGI-20260929 to gather industry feedback for the Pacific Greenfield initiative. This effort aims to establish advanced manufacturing and industrial resilience capabilities on existing non-excess Navy property on Oahu, Hawaii. The primary goal is to reduce reliance on long-lead continental United States supply chains by enabling theater-scale production of critical components, including metals, composites, electronics, and large-format printing, with a target capacity of hundreds to thousands of units. The Navy is seeking information on industrial-scale facility concepts, modern manufacturing footprints, and the integration of robust utility infrastructure, such as microgrids and circular resource-recovery systems, while emphasizing the development of the local Hawaii workforce through training pipelines. This RFI is strictly for market research and planning purposes and does not constitute a solicitation or a commitment to award a contract. The Navy is exploring various acquisition and partnership models, including Enhanced Use Leases, Other Transaction Agreements, and joint ventures, to leverage private investment and reduce federal capital requirements. Interested parties, including specialized small businesses, are invited to submit high-level concepts addressing site requirements, financing approaches, and development timelines. Responses are limited to 20 pages and must be submitted by 17:00 HST on November 10, 2026. Potential respondents are cautioned regarding possible organizational conflicts of interest related to the project's advisory and real-estate requirements.
Navfacsyscom Pacific

POSTED

about 12 hours ago

DEADLINE

in 12 days
View Details
NAICS: 541715
New
Federal
ACC-DTA Commercial Solutions Opening (CSO)
Solicitation # W912CH-26-S-0001
The Army Contracting Command – Detroit Arsenal (ACC-DTA) Commercial Solutions Opening (CSO), solicitation W912CH-26-S-0001, serves as a rapid-acquisition gateway to transition cutting-edge commercial technologies into active defense programs. This vehicle supports a diverse customer base, including the Intelligence and Security Command (INSCOM) and six Portfolio Acquisition Executives, focusing on the development, integration, and sustainment of ground vehicle systems to enhance Army modernization and readiness. The CSO utilizes a streamlined, merit-based, multi-phased evaluation process consisting of solution briefs, presentations, and commercial solution proposals. Awards may be issued through 2028 via FAR Part 12 commercial procedures or non-FAR agreements, such as transaction agreements under 10 U.S.C. 4022 and Cooperative Agreements under 31 U.S.C. 6305. The solicitation encompasses various Areas of Interest (AoI) targeting critical capabilities, including the FALCONS prototype for long-range reconnaissance, TIGER Readiness for the Abrams Main Battle Tank engine supply chain, Counter-Unmanned Aircraft Systems (C-UAS) detection, and the Light Tactical Trailer Heavy Chassis (LTT-HC). Funding ceilings for specific prototypes, such as FALCONS, range from 24 million to 30 million dollars depending on the use of government-provided kits. Key requirements include strict adherence to the Buy American Act and Specialty Metals clauses, with a prohibition on reliance on adversarial foreign nations for critical minerals. Technical evaluations focus on mission viability, affordability, and schedule realism, while administrative requirements include SAM registration, a Unique Entity ID, and compliance with NIST SP 800-171 for handling controlled unclassified information.
W6QK Acc- Dta

POSTED

about 12 hours ago

DEADLINE

in about 2 years
View Details
NAICS: 541715
New
Federal
ARTIFICIAL INTELLIGENCE AND NEXT GENERATION DISTRIBUTED COMMAND AND CONTROL
Solicitation # FA875023S7006
The Department of the Air Force, Air Force Materiel Command, AFRL Rome Research Site, is soliciting research and development for Artificial Intelligence and Next Generation Distributed Command and Control under BAA FA8750-23-S-7006. The primary objective is to transform Joint Force Command and Control capabilities by leveraging AI to enhance battlespace assessment, plan selection, and force monitoring in distributed and contested environments. A significant focus is placed on the Battle Management of AI, which seeks technologies to monitor, adapt, and deploy AI capabilities during mission execution to counter model drift and ensure operational safety. This is an open, two-step BAA effective until August 30, 2028, with total estimated funding of approximately $99 million. Individual awards typically range from $200,000 to $20 million and may be awarded as FAR-based procurement contracts, grants, cooperative agreements, or Other Transactions. Initial submissions are limited to three-page white papers, with formal proposals accepted by invitation only. Evaluation is based on a trade-off process considering overall scientific and technical merit, related experience, solution maturity and openness, and cost realism. Prospective offerors must adhere to strict guidelines, including the Gold Standard Science principles for reproducibility and transparency, and must disclose any potential Organizational Conflicts of Interest. Submissions require a CAGE code, unique entity identifier, and an approved DD Form 2345. The government may provide Government Furnished Software for specific technical areas, and all research must comply with National Industrial Security Program standards for the protection of classified information.
FA8750 Afrl Rik

POSTED

about 12 hours ago

DEADLINE

in almost 2 years
View Details

More opportunities from Department Of Health And Human Services → National Institutes Of Health

Same awarding agency

NAICS: 541715
Grant
Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource-Constrained Settings--Implementation Science Network (PATC3H-IN)The Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN) is a National Institutes of Health initiative focused on conducting implementation science research to combat adolescent HIV. By developing and testing scalable, low-resource care delivery models in low- and middle-income countries, the network aims to generate robust evidence on HIV incidence, prevention uptake, and viral suppression. These international studies leverage large adolescent populations and innovative, cost-effective service delivery methods to create practice-ready strategies that can be adapted for marginalized and high-burden populations within the United States. The program addresses critical gaps in the U.S. healthcare system where adolescents face similar barriers to care as those in resource-constrained global settings, including poverty, stigma, and fragmented services. Comprising Clinical Research Centers and a Data and Coordinating Center, PATC3H-IN supports the goals of the Ending the HIV Epidemic in the U.S. initiative by accelerating the translation of resilient and cost-conscious care models into domestic practice. This effort is authorized under the Eunice Kennedy Shriver National Institute of Child Health and Human Development to improve overall care outcomes and prevent new HIV acquisitions among at-risk youth.
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

10 days ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
CAPSTONE Centers for Multidisciplinary Research in Child Abuse and NeglectThe CAPSTONE Centers for Multidisciplinary Research in Child Abuse and Neglect is a forecast opportunity from the National Institutes of Health under the Department of Health and Human Services. This initiative focuses on child sexual abuse as a critical public health issue, aiming to overcome ethical and methodological barriers to better understand and prevent its lifelong developmental and health consequences. The program emphasizes translational research to create measurable public health impacts rather than solely identifying risk factors. The initiative utilizes a collaborative P50 mechanism to establish national resources for high-quality research. Key areas of focus include evaluating intervention efficacy, conducting longitudinal studies on chronic disease outcomes, researching biological embedding, and improving data infrastructure. The program is managed by the Pediatric Trauma and Critical Illness Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

10 days ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
Learning Disabilities Research CentersThe National Institutes of Health, through the Eunice Kennedy Shriver National Institute of Child Health and Human Development, is forecasting an opportunity to support transdisciplinary research centers dedicated to improving outcomes for children and youth with specific learning disabilities in mathematics, reading, and writing. These centers will prioritize enhancing the identification and classification of these disabilities while exploring their genetic and neurobiological foundations and testing innovative screening and intervention methods. Beyond primary research, the funded centers are expected to leverage their infrastructure to collaborate with key stakeholders and provide project-based mentorship for emerging researchers in the field of learning disabilities. This initiative is authorized under several sections of the U.S. Code to advance the understanding and treatment of these developmental challenges.
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

10 days ago

DEADLINE

N/A
View Details
NAICS: 541714
Grant
Discovery Gateway to Reproductive Health InnovationThe National Institutes of Health, through the Eunice Kennedy Shriver National Institute of Child Health and Human Development, intends to establish the Discovery Gateway to Reproductive Health Innovation. This initiative aims to create a comprehensive, open-access web-based visualization platform and knowledgebase to advance research on male and female reproductive health issues, including infertility, uterine fibroids, endometriosis, preeclampsia, and preterm birth. By integrating multi-omic, pharmacogenomic, and clinical data, the Gateway seeks to fill critical knowledge gaps and provide the biomedical community with shared infrastructure to identify biomarkers, drug targets, and disease mechanisms. The primary objective of this project is to catalyze the discovery of new treatments and cures while fostering public-private partnerships and the development of commercial products. This effort aligns with recommendations from the Task Force on Research Specific to Pregnant Women and Lactating Women. The opportunity is currently listed as a forecast, with administrative oversight provided by the Obstetric and Pediatric Pharmacology and Therapeutics Branch.
Research and Development in Biotechnology (except Nanobiotechnology)

POSTED

10 days ago

DEADLINE

N/A
View Details
NAICS: 541714
Grant
Testing Centers for Evaluation of Somatic Cell Genome Editing Approaches for Translational Applications (U42 Clinical Trial Not Allowed)The National Institutes of Health is seeking applicants to establish Testing Centers for Evaluation of Somatic Cell Genome Editing Approaches for Translational Applications. These centers will provide essential resources and testing services to the biomedical community to advance the development of genome editing technologies for treating human diseases. By collaborating with NIH-funded investigators, the centers will evaluate the efficacy and safety of delivery technologies, establish editing thresholds to minimize off-target effects, and determine feasibility within various model systems. The initiative emphasizes the creation of in vivo and in vitro research models, with a specific interest in new approach methodologies and human-biology-based models to complement traditional methods. Testing Centers are expected to develop standardized assays and operating procedures to ensure scientific rigor and reproducibility. While focusing on a limited number of initial projects, these centers will build adaptable core systems designed to support a wide range of diseases and offer fee-for-service resources on a local, regional, and national scale.
Research and Development in Biotechnology (except Nanobiotechnology)

POSTED

17 days ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
Coordinating Center for the Claude D. Pepper Older Americans Independence Centers (OAICs)The National Institute on Aging, under the Department of Health and Human Services, intends to publish a Notice of Funding Opportunity for the Coordinating Center of the Claude D. Pepper Older Americans Independence Centers program. This center will act as a facilitator for site interactions and translate program objectives and findings for scientific and general audiences. The selected entity must possess significant scientific expertise in geriatrics and a proven track record of coordinating complex multi-site projects. This announcement serves as a forecast to allow potential applicants time to establish collaborations before the official solicitation is released. The funding opportunity will utilize the U24 activity code. Interested investigators with expertise in aging research are encouraged to prepare for the upcoming application process.
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

17 days ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), Research Program (U19 Clinical Trial Optional)The National Institute on Alcohol Abuse and Alcoholism, under the Department of Health and Human Services, intends to issue a Notice of Funding Opportunity to continue the Collaborative Initiative on Fetal Alcohol Spectrum Disorders. This multidisciplinary research consortium focuses on a wide range of studies, including basic, clinical, translational, diagnostic, intervention, and prevention research aimed at addressing the lifelong physical, cognitive, and behavioral impairments caused by prenatal alcohol exposure. The program seeks to support high-priority needs such as improving early identification and diagnosis, validating interventions, and exploring the mechanisms of alcohol teratogenesis to reduce the incidence of these disorders. Successful projects must demonstrate strong integration with the broader consortium through the use of shared resources, coordinated data activities, and multidisciplinary expertise. This forecast indicates a research program where clinical trials are optional.
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

24 days ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
Centers for Research on Neglected Infectious DiseasesThe National Institute of Allergy and Infectious Diseases, under the National Institutes of Health, is establishing the Centers for Research on Neglected Infectious Diseases to combat communicable viral, bacterial, parasitic, and fungal infections. This initiative focuses on the epidemiology, pathogenesis, diagnosis, treatment, and prevention of parasitic neglected infectious diseases within endemic regions. By building sustainable in-country research capacity and expertise, the program aims to identify, contain, and mitigate these diseases at their source to protect global health and reduce the risk of spread within the United States. This opportunity is issued as a forecast by the Department of Health and Human Services and is governed by the Public Health Service Act and Federal Regulations 42 CFR Part 52 and 2 CFR Part 200. Interested parties can coordinate with the Division of Microbiology and Infectious Diseases for further information. The program emphasizes a multidisciplinary approach to research and training to address the substantial morbidity and mortality associated with understudied infectious diseases.
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

24 days ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
HIV Prevention and Alcohol (R61/R33 Clinical Trials Optional)The National Institutes of Health, under the Department of Health and Human Services, is offering a Phased Innovation Award to advance innovative HIV prevention interventions. This funding opportunity utilizes a two-stage R61/R33 structure to move research from initial development and feasibility testing to larger-scale efficacy and implementation studies. The initial R61 phase focuses on the development, refinement, and pilot testing of novel strategies to address critical scientific and operational questions, ensuring readiness for expanded evaluation across diverse populations. Upon the successful completion of R61 milestones, the R33 phase provides support for expanded testing of interventions and implementation strategies. These studies may evaluate the scalability, sustainability, and clinical management of HIV prevention interventions, specifically including integrated approaches that address alcohol use and related comorbidities. Interested parties can contact the HIV/AIDS and Alcohol Research Program for further information.
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

29 days ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
Early to Definitive Clinical Trials (R61/R33 Clinical Trial Required)The National Institutes of Health is forecasting a Notice of Funding Opportunity to solicit applications for early to definitive clinical trials. This initiative seeks proposals testing a wide range of interventions, including drugs, devices, biologics, procedures, and behavioral or social interventions, provided they align with the research missions of the participating NIH Institutes, Centers, and Offices. The funding will utilize a bi-phasic, milestone-driven R61/R33 activity code with a maximum project period of seven years. The R61 phase focuses on planning activities, while the R33 phase supports the actual clinical trial. Although applications are not currently being accepted, this notice serves as an advance alert for investigators with expertise in trial design, implementation, and stakeholder engagement to begin developing collaborations and projects.
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

about 1 month ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
Continuation of the Exceptional Longevity Data Management and Coordinating Center (EL DMCC) (U24 Clinical Trial Not Allowed)The National Institute on Aging intends to issue a single U24 cooperative agreement award to support the continued operation and expansion of the Exceptional Longevity Data Management and Coordinating Center. Serving as the central hub for human longevity translational research, the center integrates deeply phenotyped cohorts and multi-omics datasets to enable cross-cohort analyses and collaborative research. Key responsibilities include data harmonization, the implementation of common data standards, and the management of the ELITE Portal, which provides the research community with secure access to analytical tools and cloud-based computational workspaces. The upcoming funding opportunity will require the Coordinating Center to expand its capabilities in artificial intelligence, machine learning, and the integration of diverse datasets across different species. Future objectives include the development of curated target knowledgebases for therapeutic targets, the enhancement of portal interoperability according to FAIR data principles, and the strengthening of community engagement through specialized training and workshops. This notice serves as a forecast to allow potential applicants to establish collaborations before the official solicitation is released.
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

about 1 month ago

DEADLINE

N/A
View Details
NAICS: 541714
Grant
Immune Drivers of Autoimmune DiseaseThe National Institute of Allergy and Infectious Diseases seeks to support the Immune Drivers of Autoimmune Disease network to investigate the triggers and early mechanisms of autoimmunity in humans. The primary goal is to develop tools for risk prediction and staging, identify pre-clinical immune mechanisms, and utilize artificial intelligence and big data to prevent autoimmune diseases. This initiative emphasizes the creation of preclinical cohorts and the use of remote recruitment and sampling to advance medical research. The network will be managed by a Coordinating Center responsible for data harmonization, sample sharing, and the administration of an Infrastructure Opportunity Fund for collaborative research projects. This forecast, issued by the National Institutes of Health under the Department of Health and Human Services, establishes a framework for shared infrastructure and steering committee oversight to identify common pathways and prevention opportunities.
Research and Development in Biotechnology (except Nanobiotechnology)

POSTED

about 1 month ago

DEADLINE

N/A
View Details

Earlier notices in this NAICS code

Posted before this notice, open and closed

NAICS: 541715
Federal
USMCC FY27 Recompete
National Envir. Satellite, Data and Info. Services

POSTED

5 months ago

DEADLINE

N/A
View Details
NAICS: 541715
Federal
Patriot SEPA (System's Engineering and Performance Analysis)
FAS-Federal Acquisition Service

POSTED

6 months ago

DEADLINE

N/A
View Details
NAICS: 541715
Federal
NIOBE
Federal Acquisition Service

POSTED

6 months ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
National Biomedical Research Centers (P50 Clinical Trial Optional)
National Institutes Of Health

POSTED

6 months ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
Authority to Accept Unsolicited Proposals for Research Partnerships Notice of Intent (NOI)
Solicitation # PDR-2600-DC-0USP
Department Of Housing And Urban Development

POSTED

6 months ago

DEADLINE

in 7 months
View Details
NAICS: 541715
Closed
Grant
Mass Market Solutions for Leveraging Robotics and AI Technologies for Home Construction Demonstration
Solicitation # PDR-2600-DC-029Q
Department Of Housing And Urban Development

POSTED

6 months ago

CLOSED

4 months ago
View Details
NAICS: 541715
Federal
FRA Office of Safety Investigations Support
Federal Railroad Administration (FRA)

POSTED

6 months ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
Intervention Research to Improve Native American Health
National Institutes Of Health

POSTED

6 months ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
DoW Toxic Exposures Translational Research Award
Solicitation # HT942526TERPTRA
Department Of The Army -- Usamraa

POSTED

6 months ago

DEADLINE

in 20 days
View Details
NAICS: 541715
Grant
NIDA Core "Center of Transformative Science" Grant Program
National Institutes Of Health

POSTED

6 months ago

DEADLINE

N/A
View Details
NAICS: 541715
Grant
DoW Toxic Exposures Investigator Initiated Research Award
Solicitation # HT942526TERPIIRA
Department Of The Army -- Usamraa

POSTED

6 months ago

DEADLINE

in 21 days
View Details
NAICS: 541715
Grant
DoW Toxic Exposures Clinical Trial Award
Solicitation # HT942526TERPCTA
Department Of The Army -- Usamraa

POSTED

6 months ago

DEADLINE

in 21 days
View Details

Ready to Pursue This Opportunity?

Get AI-powered intelligence on this solicitation and the ones like it

Every page of the solicitation package shredded into a compliance breakdown

AI-powered matching based on your capabilities and past performance

Competitor and incumbent history on the requirement

Automated alerts on amendments, Q&A deadlines, and award

Miguel
Hillary
Keith Deutsch
Christine

Join 750+ contractors already using CLEATUS