Clinical Trials in Organ Transplantation in Children and Adults
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The National Institute of Allergy and Infectious Diseases, under the Department of Health and Human Services, is forecasting the Clinical Trials in Organ Transplantation in Children and Adults program. This initiative aims to enhance organ transplantation outcomes through multicenter clinical trials and associated mechanistic studies focusing on the heart, lung, kidney, liver, and intestinal systems. The program extends its scope to include clinical trials for non-hematopoietic cellular transplantation as replacement therapies, vascularized composite tissue transplantation, and the use of bone marrow, mesenchymal stem cells, or immunologically active cells as adjuncts to organ transplantation. This opportunity is governed by the Public Health Service Act and relevant federal regulations, with administrative oversight provided by the DAIT Transplantation Branch Clinical Trial Leadership.
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Full Description
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission through the continued support of the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. The goal of the CTOT-CA is to improve the outcome of organ transplantation through clinical trials with mechanistic studies. The CTOT-CA will support multicenter clinical trials, with associated studies of immune mechanisms, in heart, lung, kidney, liver, and intestinal transplantation. The program will also support clinical trials of non-hematopoietic cellular transplantation as replacement therapies; vascularized composite tissue transplantation; and transplantation of bone marrow or mesenchymal stem cells, or of immunologically active cells, as adjuncts to organ transplantation. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
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